Cofilin and actin dynamics: multiple modes of regulation and their impacts in neuronal development and degeneration

JR Bamburg, LS Minamide, ON Wiggan… - Cells, 2021 - mdpi.com
Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among
eukaryotes and are essential regulators of actin dynamics and function. Mammalian neurons …

Role of cyclins and Cytoskeletal Proteins in endometriosis: insights into pathophysiology

M Szymański, K Bonowicz, P Antosik, D Jerka… - Cancers, 2024 - mdpi.com
Simple Summary This article explores the cellular and molecular intricacies of
endometriosis, a gynecological condition marked by the abnormal growth of endometrium …

[HTML][HTML] Role of actin-binding proteins in the regulation of cellular mechanics

AV Vakhrusheva, AV Murashko, ES Trifonova… - European Journal of …, 2022 - Elsevier
The viscoelastic parameters of the cell can report on the cell state, cellular processes and
diseases. Cell mechanics strongly rely on the properties of the cytoskeleton, an important …

Tropomyosin 3 (TPM3) function in skeletal muscle and in myopathy

MR Lambert, E Gussoni - Skeletal Muscle, 2023 - Springer
Abstract The tropomyosin genes (TPM1-4) contribute to the functional diversity of skeletal
muscle fibers. Since its discovery in 1988, the TPM3 gene has been recognized as an …

The MYO 6 interactome: selective motor‐cargo complexes for diverse cellular processes

JJ de Jonge, C Batters, T O'Loughlin, SD Arden… - FEBS …, 2019 - Wiley Online Library
Myosins of class VI (MYO 6) are unique actin‐based motor proteins that move cargo towards
the minus ends of actin filaments. As the sole myosin with this directionality, it is critically …

Changes Induced by P2X7 Receptor Stimulation of Human Glioblastoma Stem Cells in the Proteome of Extracellular Vesicles Isolated from Their Secretome

F Di Giuseppe, L Ricci-Vitiani, R Pallini, R Di Pietro… - Cells, 2024 - mdpi.com
Extracellular vesicles (EVs) are secreted from many tumors, including glioblastoma
multiforme (GBM), the most common and lethal brain tumor in adults, which shows high …

Myosin's powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin

MJ Rynkiewicz, MC Childers, OE Karpicheva… - Journal of General …, 2024 - rupress.org
Dynamic interactions between the myosin motor head on thick filaments and the actin
molecular track on thin filaments drive the myosin-crossbridge cycle that powers muscle …

[HTML][HTML] Potential significance of serum autoantibodies to endometrial antigens, α-Enolase and hormones in non-invasive diagnosis and pathogenesis of …

IV Menzhinskaya, SV Pavlovich… - International journal of …, 2023 - mdpi.com
The objective of the study was to evaluate the profile of serum autoantibodies and their
diagnostic and pathogenetic significance in ovarian endometrioma (OEM) and deep …

Impact of the actin cytoskeleton on cell development and function mediated via tropomyosin isoforms

EC Hardeman, NS Bryce, PW Gunning - Seminars in cell & developmental …, 2020 - Elsevier
The physiological function of actin filaments is challenging to dissect because of the
pleiotropic impact of global disruption of the actin cytoskeleton. Tropomyosin isoforms have …

Impairment of rigidity sensing caused by mutant TP53 gain of function in osteosarcoma

M Luo, M Huang, N Yang, Y Zhu, P Huang, Z Xu… - Bone Research, 2023 - nature.com
Osteosarcoma (OS) is the most common primary malignant pediatric bone tumor and is
characterized by high heterogeneity. Studies have revealed a wide range of phenotypic …