Genome editing, which involves the precise manipulation of cellular DNA sequences to alter
cell fates and organism traits, has the potential to both improve our understanding of human …

Genome editing technologies operate by inducing site-specific DNA perturbations that are
resolved by cellular DNA repair pathways. Products of genome editors include DNA breaks …

Genome editing has therapeutic potential for treating genetic diseases and cancer.
However, the currently most practicable approaches rely on the generation of DNA double …

Correction of disease-causing mutations in human embryos holds the potential to reduce the
burden of inherited genetic disorders and improve fertility treatments for couples with …

Despite their fundamental biological and clinical importance, the molecular mechanisms that
regulate the first cell fate decisions in the human embryo are not well understood. Here we …

CRISPR-Cas9 genome editing is a promising technique for clinical applications, such as the
correction of disease-associated alleles in somatic cells. The use of this approach has also …

Most human embryos are aneuploid. Aneuploidy frequently arises during the early mitotic
divisions of the embryo, but its origin remains elusive. Human zygotes that cluster their …

CRISPR/Cas9-mediated gene editing has great potential utility for treating genetic diseases.
However, its therapeutic applications are limited by unintended genomic alterations arising …

The development of clustered regularly interspaced short-palindromic repeat (CRISPR)-Cas
systems for genome editing has transformed the way life science research is conducted and …

Central to the core principle of cell theory, depicting cells' history, state and fate is a
fundamental goal in modern biology. By leveraging clonal analysis and single-cell RNA-seq …