Significance: Cytochrome bd is a ubiquinol: oxygen oxidoreductase of many prokaryotic
respiratory chains with a unique structure and functional characteristics. Its primary role is to …

The contribution of biofilms to virulence and as a barrier to treatment is well-established for
Staphylococcus aureus and Enterococcus faecalis, both nosocomial pathogens frequently …

The CydDC complex of Escherichia coli is a heterodimeric ATP-binding cassette (ABC)
transporter that exports cysteine and glutathione to the periplasm. These reductants are …

Heme is a cofactor with myriad roles and essential to almost all living organisms. Beyond
classical gas transport and catalytic functions, heme is increasingly appreciated as a tightly …

Heme iron has many and varied roles in biology. Most commonly it binds as a prosthetic
group to proteins, and it has been widely supposed and amply demonstrated that subtle …

Iron is an essential nutrient for bacterial growth but poorly bioavailable. Bacteria scavenge
ferric iron by synthesizing and secreting siderophores, small compounds with a high affinity …

Iron-bound cyclic tetrapyrroles (hemes) are redox-active cofactors in bioenergetic enzymes.
However, the mechanisms of heme transport and insertion into respiratory chain complexes …

The glutathione/cysteine exporter CydDC maintains redox balance in Escherichia coli. A
cydD mutant strain was used to probe the influence of CydDC upon reduced thiol export …

Background Microbial production of chemicals from renewable carbon sources enables a
sustainable route to many bioproducts. Sugar streams, such as those derived from biomass …

l-cysteine is the source of all bacterial sulfurous biomolecules. However, the cytoplasmic
level of l-cysteine must be tightly regulated due to its propensity to reduce iron and drive …