Abstract Type 2 diabetes (T2DM) is a persistent metabolic disorder rising rapidly worldwide.
It is characterized by pancreatic insulin resistance and β-cell dysfunction. Hyperglycemia …

Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …

Diabetic sensorimotor peripheral neuropathy (DSPN) is a serious complication of diabetes
mellitus and is associated with increased mortality, lower-limb amputations and distressing …

Proliferative diabetic retinopathy (PDR) the sequel of diabetic retinopathy (DR), a frequent
complication of diabetes mellitus (DM), is the leading cause of blindness in the working-age …

Flavonoids are plant bioactive compounds of great interest in nutrition and pharmacology,
due to their remarkable properties as antioxidant, anti-inflammatory, antibacterial, antifungal …

The formation and accumulation of methylglyoxal (MGO), a highly reactive dicarbonyl
compound, has been implicated in the pathogenesis of type 2 diabetes, vascular …

Diabetic peripheral neuropathy (DPN) is a common complication of both type 1 and 2
diabetes. It is a leading cause of lower-limb amputation and disabling neuropathic pain …

Diabetes represents a spectrum of disease in which metabolic dysfunction damages
multiple organ systems including liver, kidneys and peripheral nerves,. Although the onset …

Diabetic peripheral neuropathy (DPN) occurs in up to half of individuals with type 1 or type 2
diabetes. DPN results from the distal-to-proximal loss of peripheral nerve function, leading to …