Epithelial-to-Mesenchymal Transition (EMT) has been shown to be crucial in tumorigenesis
where the EMT program enhances metastasis, chemoresistance and tumor stemness. Due …

Cardiomyocytes exit the cell cycle and become terminally differentiated soon after birth.
Therefore, in the adult heart, instead of an increase in cardiomyocyte number, individual …

YAP and TAZ are highly related transcriptional regulators pervasively activated in human
malignancies. Recent work indicates that, remarkably, YAP/TAZ are essential for cancer …

Abstract The Hippo–YAP (Yes-associated protein) pathway is an evolutionarily and
functionally conserved regulator of organ size and growth with crucial roles in cell …

Modulating signaling pathways including Wnt and Hippo can induce cardiomyocyte
proliferation in vivo. Applying these signaling modulators to human induced pluripotent stem …

Specialized adult somatic cells, such as cardiomyocytes (CMs), are highly differentiated with
poor renewal capacity, an integral reason underlying organ failure in disease and aging …

Cardiomyocyte loss after injury results in adverse remodelling and fibrosis, inevitably
leading to heart failure. The ERBB2–Neuregulin and Hippo–YAP signalling pathways are …

Epithelial and endothelial monolayers are multicellular sheets that form barriers between the
'outside'and 'inside'of tissues. Cell-cell junctions, made by adherens junctions, tight junctions …

The regenerative capacity of the adult mammalian heart is limited, because of the reduced
ability of cardiomyocytes to progress through mitosis. Endogenous cardiomyocytes have …

Background: Adult mammalian hearts have a limited ability to generate new cardiomyocytes.
Proliferation of existing adult cardiomyocytes (ACMs) is a potential source of new …