Cerebral hemorrhage: pathophysiology, treatment, and future directions
Intracerebral hemorrhage (ICH) is a devastating form of stroke with high morbidity and
mortality. This review article focuses on the epidemiology, cause, mechanisms of injury …
mortality. This review article focuses on the epidemiology, cause, mechanisms of injury …
Applications of focused ultrasound-mediated blood-brain barrier opening
The blood brain barrier (BBB) plays a critically important role in the regulation of central
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …
nervous system (CNS) homeostasis, but also represents a major limitation to treatments of …
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain
S Sirko, C Schichor, P Della Vecchia, F Metzger… - Nature Medicine, 2023 - nature.com
The glial environment influences neurological disease progression, yet much of our
knowledge still relies on preclinical animal studies, especially regarding astrocyte …
knowledge still relies on preclinical animal studies, especially regarding astrocyte …
Gut microbes in cerebrovascular diseases: gut flora imbalance, potential impact mechanisms and promising treatment strategies
X Zou, L Wang, L **ao, S Wang, L Zhang - Frontiers in immunology, 2022 - frontiersin.org
The high morbidity, mortality, and disability rates associated with cerebrovascular disease
(CeVD) pose a severe danger to human health. Gut bacteria significantly affect the onset …
(CeVD) pose a severe danger to human health. Gut bacteria significantly affect the onset …
Therapeutic blood-brain barrier modulation and stroke treatment by a bioengineered FZD4-selective WNT surrogate in mice
J Ding, SJ Lee, L Vlahos, K Yuki, CC Rada… - Nature …, 2023 - nature.com
Derangements of the blood-brain barrier (BBB) or blood-retinal barrier (BRB) occur in
disorders ranging from stroke, cancer, diabetic retinopathy, and Alzheimer's disease. The …
disorders ranging from stroke, cancer, diabetic retinopathy, and Alzheimer's disease. The …
A human model of arteriovenous malformation (AVM)-on-a-chip reproduces key disease hallmarks and enables drug testing in perfused human vessel networks
Brain arteriovenous malformations (AVMs) are a disorder wherein abnormal, enlarged blood
vessels connect arteries directly to veins, without an intervening capillary bed. AVMs are one …
vessels connect arteries directly to veins, without an intervening capillary bed. AVMs are one …
GNA14 and GNAQ somatic mutations cause spinal and intracranial extra-axial cavernous hemangiomas
J Ren, Z Cui, C Jiang, L Wang, Y Guan, Y Ren… - The American Journal of …, 2024 - cell.com
Extra-axial cavernous hemangiomas (ECHs) are complex vascular lesions mainly found in
the spine and cavernous sinus. Their removal poses significant risk due to their vascularity …
the spine and cavernous sinus. Their removal poses significant risk due to their vascularity …
Neuroinflammation plays a critical role in cerebral cavernous malformation disease
CC Lai, B Nelsen, E Frias-Anaya… - Circulation …, 2022 - Am Heart Assoc
Background: Cerebral cavernous malformations (CCMs) are neurovascular lesions caused
by loss of function mutations in 1 of 3 genes, including KRIT1 (CCM1), CCM2, and PDCD10 …
by loss of function mutations in 1 of 3 genes, including KRIT1 (CCM1), CCM2, and PDCD10 …
Somatic variants of MAP3K3 are sufficient to cause cerebral and spinal cord cavernous malformations
J Ren, Y Huang, Y Ren, T Tu, B Qiu, D Ai, Z Bi, X Bai… - Brain, 2023 - academic.oup.com
Cerebral cavernous malformations (CCMs) and spinal cord cavernous malformations
(SCCMs) are common vascular abnormalities of the CNS that can lead to seizure …
(SCCMs) are common vascular abnormalities of the CNS that can lead to seizure …
Tumor microenvironment-responsive degradable silica nanoparticles: design principles and precision theranostic applications
J Zhang, K Tang, Z Liu, Z Zhang, S Duan, H Wang… - Nanoscale …, 2024 - pubs.rsc.org
Silica nanoparticles have emerged as promising candidates in the field of nanomedicine
due to their remarkable versatility and customizable properties. However, concerns about …
due to their remarkable versatility and customizable properties. However, concerns about …