Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …

We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …

Knowing the sequence specificities of DNA-and RNA-binding proteins is essential for
develo** models of the regulatory processes in biological systems and for identifying …

Super-enhancers are large clusters of transcriptional enhancers that drive expression of
genes that define cell identity. Improved understanding of the roles that super-enhancers …

Characterized primarily by a low body-mass index, anorexia nervosa is a complex and
serious illness, affecting 0.9–4% of women and 0.3% of men,–, with twin-based heritability …

Understanding how transcriptional enhancers control over 20,000 protein-coding genes to
maintain cell-type-specific gene expression programs in all human cells is a fundamental …

Aspirin (acetylsalicylic acid) has become one of the most commonly used drugs, given its
role as an analgesic, antipyretic and agent for cardiovascular prophylaxis. Several decades …

Genome-wide association studies have identified many noncoding variants associated with
common diseases and traits. We show that these variants are concentrated in regulatory …

A large number of genes associated with various cancer types contain single nucleotide
polymorphisms (SNPs). SNPs are located in gene promoters, exons, introns as well as 5' …

MYC regulates a complex biological program by transcriptionally activating and repressing
its numerous target genes. As such, MYC is a master regulator of many processes, including …