Applications of genome editing technology in the targeted therapy of human diseases: mechanisms, advances and prospects
H Li, Y Yang, W Hong, M Huang, M Wu… - Signal transduction and …, 2020 - nature.com
Based on engineered or bacterial nucleases, the development of genome editing
technologies has opened up the possibility of directly targeting and modifying genomic …
technologies has opened up the possibility of directly targeting and modifying genomic …
[HTML][HTML] Strategies to overcome the main challenges of the use of CRISPR/Cas9 as a replacement for cancer therapy
CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats-associated protein
9) shows the opportunity to treat a diverse array of untreated various genetic and …
9) shows the opportunity to treat a diverse array of untreated various genetic and …
[HTML][HTML] Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing
CRISPR-Cas9 has emerged as a powerful technology that relies on Cas9/sgRNA
ribonucleoprotein complexes (RNPs) to target and edit DNA. However, many therapeutic …
ribonucleoprotein complexes (RNPs) to target and edit DNA. However, many therapeutic …
CRISPR-Cas9 genome editing using targeted lipid nanoparticles for cancer therapy
Harnessing CRISPR-Cas9 technology for cancer therapeutics has been hampered by low
editing efficiency in tumors and potential toxicity of existing delivery systems. Here, we …
editing efficiency in tumors and potential toxicity of existing delivery systems. Here, we …
A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing
Delivery technologies for the CRISPR-Cas9 (CRISPR, clustered regularly interspaced short
palindromic repeats) gene editing system often require viral vectors, which pose safety …
palindromic repeats) gene editing system often require viral vectors, which pose safety …
Delivery strategies of the CRISPR-Cas9 gene-editing system for therapeutic applications
The CRISPR-Cas9 genome-editing system is a part of the adaptive immune system in
archaea and bacteria to defend against invasive nucleic acids from phages and plasmids …
archaea and bacteria to defend against invasive nucleic acids from phages and plasmids …
Surface chemistry of gold nanoparticles for health-related applications
Functionalization of gold nanoparticles is crucial for the effective utilization of these materials
in health-related applications. Health-related applications of gold nanoparticles rely on the …
in health-related applications. Health-related applications of gold nanoparticles rely on the …
Endosomal escape and delivery of CRISPR/Cas9 genome editing machinery enabled by nanoscale zeolitic imidazolate framework
CRISPR/Cas9 is a combined protein (Cas9) and an engineered single guide RNA (sgRNA)
genome editing platform that offers revolutionary solutions to genetic diseases. It has …
genome editing platform that offers revolutionary solutions to genetic diseases. It has …
Gene therapy for drug-resistant glioblastoma via lipid-polymer hybrid nanoparticles combined with focused ultrasound
Q Yang, Y Zhou, J Chen, N Huang… - International journal of …, 2021 - Taylor & Francis
Background Therapy for glioblastoma (GBM) has always been very challenging, not only
because of the presence of the blood-brain barrier (BBB) but also due to susceptibility to …
because of the presence of the blood-brain barrier (BBB) but also due to susceptibility to …
[HTML][HTML] CRISPR-Cas systems: Overview, innovations and applications in human disease research and gene therapy
Y Xu, Z Li - Computational and structural biotechnology journal, 2020 - Elsevier
Genome editing is the modification of genomic DNA at a specific target site in a wide variety
of cell types and organisms, including insertion, deletion and replacement of DNA, resulting …
of cell types and organisms, including insertion, deletion and replacement of DNA, resulting …