[HTML][HTML] The hallmarks of aging
Aging is characterized by a progressive loss of physiological integrity, leading to impaired
function and increased vulnerability to death. This deterioration is the primary risk factor for …
function and increased vulnerability to death. This deterioration is the primary risk factor for …
Induced pluripotent stem cells: the new patient?
Worldwide increases in life expectancy have been paralleled by a greater prevalence of
chronic and age-associated disorders, particularly of the cardiovascular, neural and …
chronic and age-associated disorders, particularly of the cardiovascular, neural and …
In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration
Targeted genome editing via engineered nucleases is an exciting area of biomedical
research and holds potential for clinical applications. Despite rapid advances in the field, in …
research and holds potential for clinical applications. Despite rapid advances in the field, in …
Repression of the antioxidant NRF2 pathway in premature aging
Hutchinson-Gilford progeria syndrome (HGPS) is a rare, invariably fatal premature aging
disorder. The disease is caused by constitutive production of progerin, a mutant form of the …
disorder. The disease is caused by constitutive production of progerin, a mutant form of the …
METTL3 counteracts premature aging via m6A-dependent stabilization of MIS12 mRNA
Z Wu, Y Shi, M Lu, M Song, Z Yu, J Wang… - Nucleic acids …, 2020 - academic.oup.com
Abstract N6-Methyladenosine (m6A) messenger RNA methylation is a well-known
epitranscriptional regulatory mechanism affecting central biological processes, but its …
epitranscriptional regulatory mechanism affecting central biological processes, but its …
Aging hallmarks: the benefits of physical exercise
World population has been continuously increasing and progressively aging. Aging is
characterized by a complex and intraindividual process associated with nine major cellular …
characterized by a complex and intraindividual process associated with nine major cellular …
Induced pluripotent stem cells—opportunities for disease modelling and drug discovery
M Grskovic, A Javaherian, B Strulovici… - Nature reviews Drug …, 2011 - nature.com
The ability to generate induced pluripotent stem cells (iPSCs) from patients, and an
increasingly refined capacity to differentiate these iPSCs into disease-relevant cell types …
increasingly refined capacity to differentiate these iPSCs into disease-relevant cell types …
[HTML][HTML] Regulation of stem cell aging by metabolism and epigenetics
Stem cell aging and exhaustion are considered important drivers of organismal aging. Age-
associated declines in stem cell function are characterized by metabolic and epigenetic …
associated declines in stem cell function are characterized by metabolic and epigenetic …
SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2
SIRT6 belongs to the mammalian homologs of Sir2 histone NAD+-dependent deacylase
family. In rodents, SIRT6 deficiency leads to aging-associated degeneration of mesodermal …
family. In rodents, SIRT6 deficiency leads to aging-associated degeneration of mesodermal …
[HTML][HTML] Mitochondrial regulation in pluripotent stem cells
Due to their fundamental role in energy production, mitochondria have been traditionally
known as the powerhouse of the cell. Recent discoveries have suggested crucial roles of …
known as the powerhouse of the cell. Recent discoveries have suggested crucial roles of …