EMT/MET plasticity in cancer and Go-or-Grow decisions in quiescence: the two sides of the same coin?

A Akhmetkaliyev, N Alibrahim, D Shafiee, E Tulchinsky - Molecular cancer, 2023 - Springer
Epithelial mesenchymal transition (EMT) and mesenchymal epithelial transition (MET) are
genetic determinants of cellular plasticity. These programs operate in physiological …

Tumor immune microenvironment during epithelial–mesenchymal transition

M Taki, K Abiko, M Ukita, R Murakami… - Clinical Cancer …, 2021 - aacrjournals.org
Epithelial–mesenchymal transition (EMT) has been shown to play a critical role in tumor
development from initiation to metastasis. EMT could be regarded as a continuum, with …

EMT factors and metabolic pathways in cancer

I Georgakopoulos-Soares, DV Chartoumpekis… - Frontiers in …, 2020 - frontiersin.org
The epithelial-mesenchymal transition (EMT) represents a biological program during which
epithelial cells lose their cell identity and acquire a mesenchymal phenotype. EMT is …

Crosstalk between peroxisome proliferator-activated receptor gamma and the canonical WNT/β-catenin pathway in chronic inflammation and oxidative stress during …

A Vallée, Y Lecarpentier - Frontiers in immunology, 2018 - frontiersin.org
Inflammation and oxidative stress are common and co-substantial pathological processes
accompanying, promoting, and even initiating numerous cancers. The canonical WNT/β …

Basal cell carcinoma: from pathophysiology to novel therapeutic approaches

L Fania, D Didona, R Morese, I Campana, V Coco… - Biomedicines, 2020 - mdpi.com
Basal cell carcinoma (BCC) is the most common human cancer worldwide, and is a subtype
of nonmelanoma skin cancer, characterized by a constantly increasing incidence due to an …

Interplay of EMT and CSC in Cancer and the Potential Therapeutic Strategies

S Tanabe, S Quader, H Cabral, R Ono - Frontiers in pharmacology, 2020 - frontiersin.org
The mechanism of epithelial-mesenchymal transition (EMT) consists of the cellular
phenotypic transition from epithelial to mesenchymal status. The cells exhibiting EMT exist in …

The microRNA-200 family: small molecules with novel roles in cancer development, progression and therapy

B Humphries, C Yang - Oncotarget, 2015 - pmc.ncbi.nlm.nih.gov
MicroRNAs (miRNAs) are a large family of small non-coding RNAs that negatively regulate
protein-coding gene expression post-transcriptionally via base pairing between the 5 …

LncRNA HULC enhances epithelial-mesenchymal transition to promote tumorigenesis and metastasis of hepatocellular carcinoma via the miR-200a-3p/ZEB1 …

SP Li, HX Xu, Y Yu, JD He, Z Wang, YJ Xu… - …, 2016 - pmc.ncbi.nlm.nih.gov
Highly upregulated in liver cancer (HULC), a lncRNA that is considered a key molecule in
human liver cancer, has recently been revealed to be involved in hepatocellular carcinoma …

H19 activates Wnt signaling and promotes osteoblast differentiation by functioning as a competing endogenous RNA

WC Liang, WM Fu, YB Wang, YX Sun, LL Xu… - Scientific reports, 2016 - nature.com
Bone homeostasis is tightly orchestrated and maintained by the balance between
osteoblasts and osteoclasts. Recent studies have greatly expanded our understanding of …

[HTML][HTML] Interplay between microRNAs and WNT/β-catenin signalling pathway regulates epithelial–mesenchymal transition in cancer

NM Ghahhari, S Babashah - European journal of cancer, 2015 - Elsevier
The WNT/β-catenin signalling implies its significance in maintaining an epithelial cell
phenotype, proper cell–cell junctions, and tissue homeostasis. Dysregulation of the …