Beyond hemostasis: platelet innate immune interactions and thromboinflammation
J Mandel, M Casari, M Stepanyan, A Martyanov… - International journal of …, 2022 - mdpi.com
There is accumulating evidence that platelets play roles beyond their traditional functions in
thrombosis and hemostasis, eg, in inflammatory processes, infection and cancer, and that …
thrombosis and hemostasis, eg, in inflammatory processes, infection and cancer, and that …
Mechanisms of platelet clearance and translation to improve platelet storage
Hundreds of billions of platelets are cleared daily from circulation via efficient and highly
regulated mechanisms. These mechanisms may be stimulated by exogenous reagents or …
regulated mechanisms. These mechanisms may be stimulated by exogenous reagents or …
Receptor-mediated cell mechanosensing
Mechanosensing describes the ability of a cell to sense mechanical cues of its
microenvironment, including not only all components of force, stress, and strain but also …
microenvironment, including not only all components of force, stress, and strain but also …
An integrin αIIbβ3 intermediate affinity state mediates biomechanical platelet aggregation
Integrins are membrane receptors that mediate cell adhesion and mechanosensing. The
structure–function relationship of integrins remains incompletely understood, despite the …
structure–function relationship of integrins remains incompletely understood, despite the …
Activation of von Willebrand factor via mechanical unfolding of its discontinuous autoinhibitory module
Von Willebrand factor (VWF) activates in response to shear flow to initiate hemostasis, while
aberrant activation could lead to thrombosis. Above a critical shear force, the A1 domain of …
aberrant activation could lead to thrombosis. Above a critical shear force, the A1 domain of …
Transplantation of umbilical cord-derived mesenchymal stem cells promotes the recovery of thin endometrium in rats
L Zhang, Y Li, YC Dong, CY Guan, S Tian, XD Lv… - Scientific Reports, 2022 - nature.com
The endometrium plays a critical role in embryo implantation and pregnancy, and a thin
uterus is recognized as a key factor in embryo implantation failure. Umbilical cord …
uterus is recognized as a key factor in embryo implantation failure. Umbilical cord …
Platelets as autonomous drones for hemostatic and immune surveillance
Platelets participate in many important physiological processes, including hemostasis and
immunity. However, despite their broad participation in these evolutionarily critical roles, the …
immunity. However, despite their broad participation in these evolutionarily critical roles, the …
Activated αIIbβ3 on platelets mediates flow-dependent NETosis via SLC44A2
Platelet-neutrophil interactions are important for innate immunity, but also contribute to the
pathogenesis of deep vein thrombosis, myocardial infarction and stroke. Here we report that …
pathogenesis of deep vein thrombosis, myocardial infarction and stroke. Here we report that …
Contribution of the von Willebrand factor/ADAMTS13 imbalance to COVID-19 coagulopathy
R Seth, TAJ McKinnon… - American Journal of …, 2022 - journals.physiology.org
The 2019 coronavirus disease (COVID-19) is the disease caused by SARS-CoV-2 infection.
Although this infection has been shown to affect the respiratory system, a high incidence of …
Although this infection has been shown to affect the respiratory system, a high incidence of …
Multi-parametric thrombus profiling microfluidics detects intensified biomechanical thrombogenesis associated with hypertension and aging
Arterial thrombosis is a leading cause of death and disability worldwide with no effective
bioassay for clinical prediction. As a symbolic feature of arterial thrombosis, severe stenosis …
bioassay for clinical prediction. As a symbolic feature of arterial thrombosis, severe stenosis …