Functional compartmentalization of cells is a universal strategy for segregating processes
that require specific components, undergo regulation by modulating concentrations of those …

Human vision is based upon four light-sensitive pigments: in dim light, it is mediated by
rhodopsin, the visual pigment in rod photoreceptors, and at higher light levels, it is mediated …

Mutations in the photopigment rhodopsin are the major cause of autosomal dominant
retinitis pigmentosa. The majority of mutations in rhodopsin lead to misfolding of the protein …

We searched for point mutations in every exon of the rhodopsin gene in 150 patients from
separate families with autosomal dominant retinitis pigmentosa. Including the 4 mutations …

Mice homozygous for the retinal degeneration slow (rds) mutation exhibit abnormal
development of photorecep tor cells, followed by their slow degeneration. We have recently …

Retinitis pigmentosa (RP) is a heterogeneous group of inherited retinal degenerations
caused by mutations in at least 50 genes. Using homozygosity map** in Ashkenazi …

purpose. The Tulp1 gene is a member of the tubby gene family with unknown function.
Mutations in the human TULP1 gene cause autosomal recessive retinitis pigmentosa. To …

Revised Manuscript Received January 16, 1990 abstract: Peripherin, a 39-kDa membrane
protein, has been previously localized to the rim region of the vertebrate rod photoreceptor …

Morphogenesis of photoreceptor outer segment disks appears to occur by an evagination of
the ciliary plasma membrane (Steinberg et al., J Comp Neurol190: 501-519,'80). We tested if …

Vertebrate photoreceptors provide an excellent system for investigating the organization and
maintenance of the membrane domains and cell polarity necessary for sensory function. In …