Oxidative stress induced antioxidant and neurotoxicity demonstrated in vivo zebrafish embryo or larval model and their normalization due to morin showing …

PK Issac, A Guru, M Velayutham, R Pachaiappan… - Life sciences, 2021 - Elsevier
Aims The study examined that morin as possible antioxidant and neuroprotective due to
oxidative stress (H 2 O 2) in zebrafish larval model. Materials and methods Zebrafish larvae …

[HTML][HTML] Physiological and clinical aspects of bioactive peptides from marine animals

S Chakniramol, A Wierschem, MG Cho, KMI Bashir - Antioxidants, 2022 - mdpi.com
Biological molecules in nutraceuticals and functional foods have proven physiological
properties to treat human chronic diseases. These molecules contribute to applications in …

Embryonic exposure to butylparaben and propylparaben induced developmental toxicity and triggered anxiety‐like neurobehavioral response associated with …

C Lite, A Guru, M Juliet… - Environmental …, 2022 - Wiley Online Library
Parabens are synthetic antimicrobial compounds used as a preservative for extending the
shelf life of food, pharmaceutical and cosmetic products. The alkyl chain length of the …

Hydroxyl containing benzo [b] thiophene analogs mitigates the acrylamide induced oxidative stress in the zebrafish larvae by stabilizing the glutathione redox cycle

B Haridevamuthu, T Manjunathan, A Guru, RS Kumar… - Life Sciences, 2022 - Elsevier
Aims This study aims to elucidate a systematic free-radical quenching ability of synthesized
benzo [b] thiophene derivatives using in vitro assays and acrylamide induced oxidatively …

Reverse pharmacology of Nimbin-N2 attenuates alcoholic liver injury and promotes the hepatoprotective dual role of improving lipid metabolism and downregulating …

G Sudhakaran, P Prathap, A Guru… - Molecular and cellular …, 2022 - Springer
Alcoholic liver disease is one of the most prominent liver diseases in the world. Lipid
accumulation accompanied by oxidative stress and inflammation in the liver is the most …

Lipid-lowering and antioxidant activity of RF13 peptide from vacuolar protein sorting-associated protein 26B (VPS26B) by modulating lipid metabolism and oxidative …

A Guru, M Velayutham, J Arockiaraj - International Journal of Peptide …, 2022 - Springer
Obesity is one of the major contributing factors responsible for the onset of various metabolic
syndrome. In obesity-related metabolic syndrome, increased oxidative stress in accumulated …

6‐Gingerol and semisynthetic 6‐gingerdione counteract oxidative stress induced by ros in zebrafish

T Manjunathan, A Guru, J Arokiaraj… - Chemistry & …, 2021 - Wiley Online Library
Gingerol (1) is one of the major components in ginger and develo** new synthetic
methodologies could bring semisynthetic analogs with improved therapeutic properties …

Anti‐inflammatory role demonstrated both in vitro and in vivo models using nonsteroidal tetranortriterpenoid, Nimbin (N1) and its analogs (N2 and N3) that alleviate …

G Sudhakaran, P Prathap, A Guru… - Cell Biology …, 2022 - Wiley Online Library
Human health may benefit from the study of natural compounds and phytoconstituents that
can protect from inflammation. We investigated Nimbin (N1), a member of the ring C Seco …

Daidzein normalized gentamicin-induced nephrotoxicity and associated pro-inflammatory cytokines in MDCK and zebrafish: Possible mechanism of nephroprotection

A Guru, G Sudhakaran, M Velayutham… - … and Physiology Part C …, 2022 - Elsevier
This study investigates the therapeutic activity of daidzein, an isoflavone that occurs
naturally in plants and herbs, against gentamicin-induced nephrotoxicity in Madin-Darby …

Textile azo dye, Sudan Black B, inducing hepatotoxicity demonstrated in in vivo zebrafish larval model

K Ramamurthy, S Madesh, PS Priya, R Ayub… - Fish Physiology and …, 2024 - Springer
Environmental pollution, particularly from textile industry effluents, raises concerns globally.
The aim of this study is to investigate the hepatotoxicity of Sudan Black B (SBB), a commonly …