Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …

Regulated fibroblast growth factor (FGF) signalling is a prerequisite for the correct
development and homeostasis of articular cartilage, as evidenced by the fact that aberrant …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

The MET tyrosine kinase receptor (also known as the HGF receptor) promotes tissue
remodelling, which underlies developmental morphogenesis, wound repair, organ …

INTRODUCTION Control of mosquito vectors has historically proven to be an effective
means of eliminating malaria. Human malaria is transmitted only by mosquitoes in the genus …

The AGC family of serine/threonine kinases (PKA, PKG, PKC) includes more than 60
members that are critical regulators of numerous cellular functions, including cell cycle and …

Introduction: Diabetic retinopathy (DR) is the leading cause of vision loss in the working age
population of the developed world. DR encompasses a complex pathology, and one that is …

The mechanistic target of rapamycin (mTOR) plays a central role in cellular growth and
metabolism. mTOR forms two distinct protein complexes, mTORC1 and mTORC2. Much is …

Summary Phosphoinositide-3-kinase (PI3K)-α inhibitors have shown clinical activity in
squamous cell carcinomas (SCCs) of head and neck (H&N) bearing PIK3CA mutations or …

The signalling pathways utilised by insulin receptor (IR) and IGF receptor to transduce their
diverse effects on cellular metabolism, growth and survival are well established in broad …