Progress in understanding the genetic etiology of autism spectrum disorders (ASD) has
fueled remarkable advances in our understanding of its potential neurobiological …

Abstract Knowledge of genetics and its implications for human health is rapidly evolving in
accordance with recent events, such as discoveries of large numbers of disease …

The vast majority of genome-wide association studies (GWASs) are performed in
Europeans, and their transferability to other populations is dependent on many factors (eg …

Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …

We introduce multi-trait analysis of GWAS (MTAG), a method for joint analysis of summary
statistics from genome-wide association studies (GWAS) of different traits, possibly from …

The genetic correlation describes the genetic relationship between two traits and can
contribute to a better understanding of the shared biological pathways and/or the causality …

We propose a taxonomy of psychopathology based on patterns of shared causal influences
identified in a review of multivariate behavior genetic studies that distinguish genetic and …

Large-scale genomic investigations have just begun to illuminate the molecular genetic
contributions to major psychiatric illnesses, ranging from small-effect-size common variants …

Transcriptome-wide association analysis is a powerful approach to studying the genetic
architecture of complex traits. A key component of this approach is to build a model to impute …

Genetics provides two major opportunities for understanding human disease—as a
transformative line of etiological inquiry and as a biomarker for heritable diseases. In …