Mounting evidence highlights the role of adipose tissue in the development of a systemic
inflammatory state that contributes to obesity-associated vasculopathy and cardiovascular …

Context: Insulin resistance is an almost universal finding in nonalcoholic fatty liver disease
(NAFLD). This review outlines the evidence linking insulin resistance and NAFLD, explores …

Nitric oxide (NO) is a molecule that has gained recognition as a crucial modulator of
vascular disease. NO has a number of intracellular effects that lead to vasorelaxation …

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear hormone
receptors family. PPARs are a family of 3 ligand-activated transcription factors: PPARα …

Women with polycystic ovary syndrome (PCOS) carry a number of cardiovascular risk
factors. Cardiovascular morbidity is elevated even in young women with PCOS. Low-grade …

Endothelial dysfunction and insulin resistance are frequently comorbid states. Vasodilator
actions of insulin are mediated by phosphatidylinositol 3-kinase (PI3K)-dependent signaling …

The metabolic syndrome (MetS) is characterized by the presence of central obesity,
impaired glucose metabolism, dyslipidemia and hypertension. Several studies showed that …

Background Metabolic syndrome is a cluster of common cardiovascular risk factors that
includes hypertension and insulin resistance. Hypertension and diabetes mellitus are …

Objectives: This study investigated the effects of rosiglitazone (RSG) on left ventricular
ejection fraction (LVEF) in subjects with type 2 diabetes (T2DM) and pre-existing chronic …

Peroxisome proliferator-activated receptors (PPAR) α, γ and β/δ belong to the nuclear
receptor family of ligand-activated transcription factors. PPARs heterodimerize with the …