The introduction of technologies such as mass spectrometry and protein and DNA arrays,
combined with our understanding of the human genome, has enabled simultaneous …

The focus of this article is to review the recent advances in proteome analysis of human
body fluids, including plasma/serum, urine, cerebrospinal fluid, saliva, bronchoalveolar …

The Religious Orders Study is a longitudinal clinical-pathologic cohort study of aging and
Alzheimer's disease (AD). In this manuscript, we summarize the study methods including the …

Alzheimer's disease is a common and devastating disease for which there is no readily
available biomarker to aid diagnosis or to monitor disease progression. Biomarkers have …

Background: Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
(MALDI-TOF MS) and the related technique, surface-enhanced laser desorption/ionization …

The low-molecular-weight range of the circulatory proteome is termed the'peptidome', and
could be a rich source of cancer-specific diagnostic information because it is a'recording'of …

There are several definitions of biomarkers. A biomarker is a characteristic that can be
objectively measured and evaluated as an indicator of a physiological as well as a …

Although a battery of neuropsychological tests is often used in making a clinical diagnosis of
Alzheimer's disease (AD), definitive diagnosis still relies on pathological evaluation at …

Disease-associated blood biomarkers exist in exceedingly low concentrations within
complex mixtures of high-abundance proteins such as albumin. We have introduced an …

Blood-based biomarkers present a considerable challenge: technically, as blood is a
complex tissue and conceptually, as blood lacks direct contact with brain. Nonetheless …