Interleukin 6 as an energy allocator in muscle tissue
Extensive research has shown that interleukin 6 (IL-6) is a multifunctional molecule that is
both proinflammatory and anti-inflammatory, depending on the context. Here, we combine …
both proinflammatory and anti-inflammatory, depending on the context. Here, we combine …
Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities
Macrophages, which are key cellular components of the liver, have emerged as essential
players in the maintenance of hepatic homeostasis and in injury and repair processes in …
players in the maintenance of hepatic homeostasis and in injury and repair processes in …
Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality
C Zhang, Z Wu, JW Li, H Zhao, GQ Wang - International journal of …, 2020 - Elsevier
Since December 2019, a viral pneumonia, named coronavirus disease 2019 (COVID-19),
from Wuhan, China, has swept the world. Although the case fatality rate is not high, the …
from Wuhan, China, has swept the world. Although the case fatality rate is not high, the …
[HTML][HTML] Adipose tissue distribution, inflammation and its metabolic consequences, including diabetes and cardiovascular disease
A Chait, LJ Den Hartigh - Frontiers in cardiovascular medicine, 2020 - frontiersin.org
Adipose tissue plays essential roles in maintaining lipid and glucose homeostasis. To date
several types of adipose tissue have been identified, namely white, brown, and beige, that …
several types of adipose tissue have been identified, namely white, brown, and beige, that …
The endocrine function of adipose tissues in health and cardiometabolic disease
L Scheja, J Heeren - Nature reviews endocrinology, 2019 - nature.com
In addition to their role in glucose and lipid metabolism, adipocytes respond differentially to
physiological cues or metabolic stress by releasing endocrine factors that regulate diverse …
physiological cues or metabolic stress by releasing endocrine factors that regulate diverse …
Single cell RNA sequencing of human liver reveals distinct intrahepatic macrophage populations
The liver is the largest solid organ in the body and is critical for metabolic and immune
functions. However, little is known about the cells that make up the human liver and its …
functions. However, little is known about the cells that make up the human liver and its …
Role of C‐reactive protein in diabetic inflammation
J Stanimirovic, J Radovanovic, K Banjac… - Mediators of …, 2022 - Wiley Online Library
Even though type 2 diabetes mellitus (T2DM) represents a worldwide chronic health issue
that affects about 462 million people, specific underlying determinants of insulin resistance …
that affects about 462 million people, specific underlying determinants of insulin resistance …
Pathophysiology of COVID-19: mechanisms underlying disease severity and progression
MK Bohn, A Hall, L Sepiashvili, B Jung… - …, 2020 - journals.physiology.org
The global epidemiology of coronavirus disease 2019 (COVID-19) suggests a wide
spectrum of clinical severity, ranging from asymptomatic to fatal. Although the clinical and …
spectrum of clinical severity, ranging from asymptomatic to fatal. Although the clinical and …
[HTML][HTML] Chimeric antigen receptor T-cell therapy—assessment and management of toxicities
SS Neelapu, S Tummala, P Kebriaei… - Nature reviews Clinical …, 2018 - nature.com
Immunotherapy using T cells genetically engineered to express a chimeric antigen receptor
(CAR) is rapidly emerging as a promising new treatment for haematological and non …
(CAR) is rapidly emerging as a promising new treatment for haematological and non …
Contribution of adipose tissue inflammation to the development of type 2 diabetes mellitus
MS Burhans, DK Hagman, JN Kuzma… - Comprehensive …, 2018 - pmc.ncbi.nlm.nih.gov
The objective of this comprehensive review is to summarize and discuss the available
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …
evidence of how adipose tissue inflammation affects insulin sensitivity and glucose …