Explosive transitions in complex networks' structure and dynamics: Percolation and synchronization

S Boccaletti, JA Almendral, S Guan, I Leyva, Z Liu… - Physics Reports, 2016‏ - Elsevier
Percolation and synchronization are two phase transitions that have been extensively
studied since already long ago. A classic result is that, in the vast majority of cases, these …

Nonlinear and stochastic dynamics in the heart

Z Qu, G Hu, A Garfinkel, JN Weiss - Physics reports, 2014‏ - Elsevier
In a normal human life span, the heart beats about 2–3 billion times. Under diseased
conditions, a heart may lose its normal rhythm and degenerate suddenly into much faster …

Cardiac alternans: from bedside to bench and back

Z Qu, JN Weiss - Circulation research, 2023‏ - ahajournals.org
Cardiac alternans arises from dynamical instabilities in the electrical and calcium cycling
systems of the heart, and often precedes ventricular arrhythmias and sudden cardiac death …

Visualization of spiral and scroll waves in simulated and experimental cardiac tissue

EM Cherry, FH Fenton - New Journal of Physics, 2008‏ - iopscience.iop.org
The heart is a nonlinear biological system that can exhibit complex electrical dynamics,
complete with period-doubling bifurcations and spiral and scroll waves that can lead to …

Calcium handling defects and cardiac arrhythmia syndromes

K Kistamas, R Veress, B Horvath, T Banyasz… - Frontiers in …, 2020‏ - frontiersin.org
Calcium ions (Ca2+) play a major role in the cardiac excitation-contraction coupling.
Intracellular Ca2+ concentration increases during systole and falls in diastole thereby …

Mechanisms of ventricular arrhythmias: from molecular fluctuations to electrical turbulence

Z Qu, JN Weiss - Annual review of physiology, 2015‏ - annualreviews.org
Ventricular arrhythmias have complex causes and mechanisms. Despite extensive
investigation involving many clinical, experimental, and computational studies, effective …

Cardiac cell modelling: observations from the heart of the cardiac physiome project

M Fink, SA Niederer, EM Cherry, FH Fenton… - Progress in biophysics …, 2011‏ - Elsevier
In this manuscript we review the state of cardiac cell modelling in the context of international
initiatives such as the IUPS Physiome and Virtual Physiological Human Projects, which aim …

Multi-scale modeling in biology: how to bridge the gaps between scales?

Z Qu, A Garfinkel, JN Weiss, M Nivala - Progress in biophysics and …, 2011‏ - Elsevier
Human physiological functions are regulated across many orders of magnitude in space and
time. Integrating the information and dynamics from one scale to another is critical for the …

Effects of pacing site and stimulation history on alternans dynamics and the development of complex spatiotemporal patterns in cardiac tissue

A Gizzi, EM Cherry, RF Gilmour Jr, S Luther… - Frontiers in …, 2013‏ - frontiersin.org
Alternans of action potential duration has been associated with T wave alternans and the
development of arrhythmias because it produces large gradients of repolarization. However …

Optogenetic manipulation of cardiac electrical dynamics using sub-threshold illumination: dissecting the role of cardiac alternans in terminating rapid rhythms

V Biasci, L Santini, GA Marchal, S Hussaini… - Basic research in …, 2022‏ - Springer
Cardiac action potential (AP) shape and propagation are regulated by several key dynamic
factors such as ion channel recovery and intracellular Ca2+ cycling. Experimental methods …