Strategy to combat biofilms: a focus on biofilm dispersal enzymes

S Wang, Y Zhao, AP Breslawec, T Liang… - npj Biofilms and …, 2023 - nature.com
Bacterial biofilms, which consist of three-dimensional extracellular polymeric substance
(EPS), not only function as signaling networks, provide nutritional support, and facilitate …

Enzymatic dispersion of biofilms: An emerging biocatalytic avenue to combat biofilm-mediated microbial infections

R Ramakrishnan, AK Singh, S Singh… - Journal of Biological …, 2022 - ASBMB
Drug resistance by pathogenic microbes has emerged as a matter of great concern to
mankind. Microorganisms such as bacteria and fungi employ multiple defense mechanisms …

The Pel polysaccharide is predominantly composed of a dimeric repeat of α-1,4 linked galactosamine and N-acetylgalactosamine

F Le Mauff, E Razvi, C Reichhardt, P Sivarajah… - Communications …, 2022 - nature.com
The genetic capacity to synthesize the biofilm matrix exopolysaccharide Pel is widespread
among Gram-negative and Gram-positive bacteria. However, its exact chemical structure …

Carbohydrate-binding modules facilitate the enzymatic hydrolysis of lignocellulosic biomass: Releasing reducing sugars and dissociative lignin available for …

Q Shi, AM Abdel-Hamid, Z Sun, Y Cheng, T Tu… - Biotechnology …, 2023 - Elsevier
The microbial decomposition and utilization of lignocellulosic biomass present in the plant
tissues are driven by a series of carbohydrate active enzymes (CAZymes) acting in concert …

Structural and mechanistic characterization of bifunctional heparan sulfate N-deacetylase-N-sulfotransferase 1

CJ Mycroft-West, S Abdelkarim… - Nature …, 2024 - nature.com
Heparan sulfate (HS) polysaccharides are major constituents of the extracellular matrix,
which are involved in myriad structural and signaling processes. Mature HS polysaccharides …

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: An update for 2019–2020

DJ Harvey - Mass Spectrometry Reviews, 2023 - Wiley Online Library
This review is the tenth update of the original article published in 1999 on the application of
matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry to the analysis of …

Conservative production of galactosaminogalactan in Metarhizium is responsible for appressorium mucilage production and topical infection of insect hosts

L Mei, X Wang, Y Yin, G Tang, C Wang - PLoS pathogens, 2021 - journals.plos.org
The exopolysaccharide galactosaminogalactan (GAG) has been well characterized in
Aspergilli, especially the human pathogen Aspergillus fumigatus. It has been found that a …

[HTML][HTML] Fungal cell wall components modulate our immune system

B Briard, T Fontaine, TD Kanneganti, NAR Gow… - The Cell Surface, 2021 - Elsevier
Invasive fungal infections remain highly problematic for human health. Collectively, they
account for more than 1 million deaths a year in addition to more than 100 million mucosal …

Ecological insights and potential application of marine filamentous fungi in environmental restoration

AD Behera, S Das - Reviews in Environmental Science and Bio …, 2023 - Springer
Marine ecosystem is a rich energy reservoir supporting diverse lifeforms. Filamentous fungi
colonize various substrates of marine ecosystems in the form of saprotrophs, parasites and …

The Transcription Factor SomA Synchronously Regulates Biofilm Formation and Cell Wall Homeostasis in Aspergillus fumigatus

Y Chen, F Le Mauff, Y Wang, R Lu, DC Sheppard, L Lu… - MBio, 2020 - Am Soc Microbiol
Polysaccharides are key components of both the fungal cell wall and biofilm matrix. Despite
having distinct assembly and regulation pathways, matrix exopolysaccharide and cell wall …