As life expectancy continues to increase worldwide, age-related dysfunction will largely
impact our societies in the future. Aging is well established to promote the deterioration of …

Cognitive control of behavior is crucial for well-being, as allows subject to adapt to changing
environments in a goal-directed way. Changes in cognitive control of behavior is observed …

Meta-analysis of genome-wide association study data has implicated PDE4B in the
pathogenesis of Alzheimer's disease (AD), the leading cause of senile dementia. PDE4B …

Cognitive processes involve precisely coordinated neuronal communications between
multiple cerebral cortical structures in a task specific manner. Rich new evidence now …

Central nervous system myelination increases action potential conduction velocity.
However, it is unclear how myelination is coordinated to ensure the temporally precise …

Therapeutic interventions have not yet been shown to demonstrate restorative effects for
declining long-term memory (LTM) that affects many healthy older adults. We developed a …

Humans are adept in simultaneously following multiple goals, but the neural mechanisms for
maintaining specific goals and distinguishing them from other goals are incompletely …

Rationale Animal studies suggest that the so-called “female” hormone estrogen enhances
spatial navigation and memory. This contradicts the observation that males generally out …

To date, neural efficiency, an ability to economically utilize mental resources, has not been
investigated after cognitive training. The purpose of this study was to provide customized …

Hyperkateifia and stress-induced alcohol cravings drive relapse in individuals with alcohol
use disorder (AUD). The brain stress signal norepinephrine (also known as noradrenaline) …