Decoding molecular interactions in microbial communities

NA Abreu, ME Taga - FEMS Microbiology Reviews, 2016 - academic.oup.com
Microbial communities govern numerous fundamental processes on earth. Discovering and
tracking molecular interactions among microbes is critical for understanding how single …

Uneven distribution of cobamide biosynthesis and dependence in bacteria predicted by comparative genomics

AN Shelton, EC Seth, KC Mok, AW Han… - The ISME …, 2019 - academic.oup.com
The vitamin B12 family of cofactors known as cobamides are essential for a variety of
microbial metabolisms. We used comparative genomics of 11,000 bacterial species to …

Cobamide structure depends on both lower ligand availability and CobT substrate specificity

TS Crofts, EC Seth, AB Hazra, ME Taga - Chemistry & biology, 2013 - cell.com
Cobamides are members of the vitamin B 12 family of cofactors that function in a variety of
metabolic processes and are synthesized only by prokaryotes. Cobamides produced by …

Cobalamin riboswitches are broadly sensitive to corrinoid cofactors to enable an efficient gene regulatory strategy

KJ Kennedy, FJ Widner, OM Sokolovskaya… - MBio, 2022 - Am Soc Microbiol
In bacteria, many essential metabolic processes are controlled by riboswitches, gene
regulatory RNAs that directly bind and detect metabolites. Highly specific effector binding …

Analysis of substrate specificity in CobT homologs reveals widespread preference for DMB, the lower axial ligand of vitamin B12

AB Hazra, JLA Tran, TS Crofts, ME Taga - Chemistry & biology, 2013 - cell.com
Cobamides such as vitamin B 12 (cobalamin) are produced exclusively by prokaryotes and
used by many other organisms as cofactors for diverse metabolic processes. Cobamides are …

Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids

S Li, AN Lowell, SA Newmister, F Yu… - Nature chemical …, 2017 - nature.com
The formation of C–C bonds in an enantioselective fashion to create complex polycyclic
scaffolds in the hapalindole-and fischerindole-type alkaloids from Stigonematales …

Regiospecific formation of cobamide isomers is directed by CobT

TS Crofts, AB Hazra, JLA Tran, OM Sokolovskaya… - Biochemistry, 2014 - ACS Publications
Cobamides, which include vitamin B12 (cobalamin), are a class of modified tetrapyrroles
synthesized exclusively by prokaryotes that function as cofactors for diverse biological …

Dissecting cobamide diversity through structural and functional analyses of the base-activating CobT enzyme of Salmonella enterica

CH Chan, SA Newmister, K Talyor, KR Claas… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Background Cobamide diversity arises from the nature of the nucleotide base. Nicotinate
mononucleotide (NaMN): base phosphoribosyltransferases (CobT) synthesize α-linked …

Study on Degradation of 1,2,4-TrCB by Sugarcane Cellulose-TiO2 Carrier in an Intimate Coupling of Photocatalysis and Biodegradation System

Z Zhou, C Jiao, Y Liang, A Du, J Zhang, J **ong… - Polymers, 2022 - mdpi.com
1, 2, 4 trichlorobenzene (1, 2, 4-TrCB) is a persistent organic pollutant with chemical stability,
biological toxicity, and durability, which has a significant adverse impact on the ecological …

Cobalamin biosynthesis and insertion

TA Mattes, E Deery, MJ Warren… - … of inorganic and …, 2011 - Wiley Online Library
Metal‐containing cyclic tetrapyrroles are widely distributed in nature, and together comprise
the family of compounds frequently referred to as “the pigments of life,” namely cobamides …