Bromelain, a Group of Pineapple Proteolytic Complex Enzymes (Ananas comosus) and Their Possible Therapeutic and Clinical Effects. A Summary

C Varilla, M Marcone, L Paiva, J Baptista - Foods, 2021 - mdpi.com
Bromelain is a complex combination of multiple endopeptidases of thiol and other
compounds derived from the pineapple fruit, stem and/or root. Fruit bromelain and stem …

Current therapeutic strategies in diabetic foot ulcers

A Perez-Favila, ML Martinez-Fierro… - Medicina, 2019 - mdpi.com
Diabetic foot ulcers (DFUs) are the fastest growing chronic complication of diabetes mellitus,
with more than 400 million people diagnosed globally, and the condition is responsible for …

Hydrogel cross-linked with dynamic covalent bonding and micellization for promoting burn wound healing

Z Li, F Zhou, Z Li, S Lin, L Chen, L Liu… - ACS applied materials & …, 2018 - ACS Publications
A novel hydrogel (HA-az-F127 hydrogel) formed by reacting hydrazide modified hyaluronic
acid (HAAD) and benzaldehyde terminated F127 triblock copolymers (BAF127) was …

[HTML][HTML] Eschar removal by bromelain based enzymatic debridement (Nexobrid®) in burns: European consensus guidelines update

C Hirche, SK Almeland, B Dheansa, P Fuchs… - Burns, 2020 - Elsevier
Abstract Introduction Bromelain-based Enzymatic Debridement has been introduced as an
additional concept to the burn surgeon's armamentarium and is best indicated for mid-to …

Bromelain-loaded chitosan nanofibers prepared by electrospinning method for burn wound healing in animal models

S Bayat, N Amiri, E Pishavar, F Kalalinia, J Movaffagh… - Life sciences, 2019 - Elsevier
Bromelain is a mixture of proteolytic enzymes present in all tissues of pineapple (Ananas
comosus). It is known as an efficient debriding agent in burn treatment. In this study, the …

Advancements in regenerative strategies through the continuum of burn care

R Stone II, S Natesan, CJ Kowalczewski… - Frontiers in …, 2018 - frontiersin.org
Burns are caused by several mechanisms including flame, scald, chemical, electrical, and
ionizing and non-ionizing radiation. Approximately half a million burn cases are registered …

Bromelain and nisin: The natural antimicrobials with high potential in biomedicine

U Jančič, S Gorgieva - Pharmaceutics, 2021 - mdpi.com
Infectious diseases along with various cancer types are among the most significant public
health problems and the leading cause of death worldwide. The situation has become even …

Bromelain-loaded silver nanoparticles: formulation, characterization and biological activity

F Gheisari, SR Kasaee, P Mohamadian… - Inorganic Chemistry …, 2024 - Elsevier
Bromelain (BL), a type of proteolytic enzymes from Ananas comosus (pineapple), has a
variety of therapeutic potentials; nevertheless, its low bioavailability has restricted the clinical …

Bromelain‐based enzymatic burn debridement: A systematic review of clinical studies on patient safety, efficacy and long‐term outcomes

Y Shoham, K Gasteratos, AJ Singer… - International Wound …, 2023 - Wiley Online Library
Abstract In 2012 the European Medicines Agency approved a pineapple stem‐derived
Bromelain‐based debridement concentrate of proteolytic enzymes (NexoBrid®, MediWound …

Molecular immunological mechanisms of impaired wound healing in diabetic foot ulcers (DFU), current therapeutic strategies and future directions

F Mohsin, S Javaid, M Tariq, M Mustafa - International …, 2024 - Elsevier
Diabetic foot ulcer (DFU) is a foremost cause of amputation in diabetic patients.
Consequences of DFU include infections, decline in limb function, hospitalization …