Small molecules regulating reactive oxygen species homeostasis for cancer therapy

J Zhang, D Duan, ZL Song, T Liu… - Medicinal Research …, 2021 - Wiley Online Library
Elevated intracellular reactive oxygen species (ROS) and antioxidant defense systems have
been recognized as one of the hallmarks of cancer cells. Compared with normal cells …

The mechanism (s) of action of antioxidants: From scavenging reactive oxygen/nitrogen species to redox signaling and the generation of bioactive secondary …

A Hunyadi - Medicinal research reviews, 2019 - Wiley Online Library
Small molecule, dietary antioxidants exert a remarkably broad range of bioactivities, and
many of these can be explained by the influence of antioxidants on the redox homeostasis …

[PDF][PDF] Synthesis and biological activities of 3, 5-disubstituted-4-hydroxycinnamic acids linked to a functionalized coumarin

MK Oglah, MK Bashir, YF Mustafa, ET Mohammed… - Syst Rev …, 2020 - academia.edu
As part of our interest in the coumarin chemical nucleus, a series of 3, 5-disubstituted-4-
hydroxycinnamic acids to which 6-hydroxy-7-methoxy-4-methyl-3-isopropylcoumarin is …

Bridging free radical chemistry with drug discovery: A promising way for finding novel drugs efficiently

ZQ Liu - European Journal of Medicinal Chemistry, 2020 - Elsevier
Many diseases have been regarded to correlate with the in vivo oxidative damages, which
are caused by overproduced free radicals from metabolic process or reactive oxygen …

[HTML][HTML] Oxidized resveratrol metabolites as potent antioxidants and xanthine oxidase inhibitors

OG Agbadua, N Kúsz, R Berkecz, T Gáti, G Tóth… - Antioxidants, 2022 - mdpi.com
Resveratrol is a well-known natural polyphenol with a plethora of pharmacological activities.
As a potent antioxidant, resveratrol is highly oxidizable and readily reacts with reactive …

A mini-review: Exploring the application prospects of the three major rules in the field of antioxidants

Y Hu, Z Zheng, D Zhai, P Liang, Z Wang… - Journal of Molecular …, 2024 - Elsevier
Antioxidants are substances that can delay or inhibit oxidation reactions and are widely
used in various fields such as medicine, cosmetics, and food industries. Although the three …

[HTML][HTML] Antioxidant and Cytoprotective Effects of (−)-Epigallocatechin-3-(3″-O-methyl) Gallate

E Kim, SY Han, K Hwang, D Kim, EM Kim… - International journal of …, 2019 - mdpi.com
Reactive oxygen species (ROS) are generated from diverse cellular processes or external
sources such as chemicals, pollutants, or ultraviolet (UV) irradiation. Accumulation of …

[HTML][HTML] A review of phytochemicals and bioactive properties in the Proteaceae family: A promising source of functional food

J Zhang, ME Netzel, A Pengelly, D Sivakumar… - Antioxidants, 2023 - mdpi.com
In recent decades, natural plant-based foods have been increasingly used to improve
human health due to unhealthy modern dietary patterns, such as the consumption of foods …

Bioactive components and anticancer activities of spray-dried New Zealand tamarillo powder

Q Liu, N Hamid, Y Liu, R Kam, K Kantono, K Wang… - Molecules, 2022 - mdpi.com
Tamarillo fruit contains many phytochemicals that have beneficial therapeutic and nutritional
properties. Spray-drying is widely used to preserve fruit puree in powder form. However, to …

Novel acrylonitrile derived imidazo [4, 5-b] pyridines as antioxidants and potent antiproliferative agents for pancreatic adenocarcinoma

IB Pavlinac, L Persoons, D Daelemans… - International journal of …, 2024 - Elsevier
We present the design, synthesis, computational analysis, and biological assessment of
several acrylonitrile derived imidazo [4, 5-b] pyridines, which were evaluated for their …