The intestinal epithelium forms the boundary between the intestinal immune system in the
lamina propria and the outside world, the intestinal lumen, which contains a diverse array of …

Intestinal epithelial tight junctions (TJs), a dynamically regulated barrier structure composed
of occludin and claudin family of proteins, mediate the interaction between the host and the …

Inflammatory bowel diseases (IBD) pose a growing public health challenge with unclear
etiology and limited efficacy of traditional pharmacological treatments. Alternative therapies …

Colorectal cancer (CRC), as the third most common bisexual cancer worldwide, requires
urgent research on its underlying mechanisms and intervention methods. NRF2 is an …

Dysregulation of both the gut barrier and microbiota (dysbiosis) promotes susceptibility to
and severity of Inflammatory Bowel Diseases (IBD). Leaky gut and dysbiosis often coexist; …

Introduction: Pre-diabetes, a high-risk metabolic state, is situated between normal glucose
homeostasis and diabetes. Early identification of pre-diabetes offers opportunities for …

Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a
complex gastrointestinal condition influenced by genetic, microbial, and environmental …

Beside the respiratory tract, the skin and the gut represent the first defensive lines of our
body against the external insults displaying many important biochemical features able to …

The intestine is prone to radiation damage in patients undergoing radiotherapy for pelvic
tumors. However, there are currently no effective drugs available for the prevention or …

This study investigated the role of Alpha-tocopherylquinone (TQ) in regulating the intestinal
immune system and the underlying mechanisms. In the experimental dextran sodium sulfate …