Regulated cell death pathways in kidney disease

AB Sanz, MD Sanchez-Niño, AM Ramos… - Nature Reviews …, 2023 - nature.com
Disorders of cell number that result from an imbalance between the death of parenchymal
cells and the proliferation or recruitment of maladaptive cells contributes to the pathogenesis …

Tubular mitochondrial dysfunction, oxidative stress, and progression of chronic kidney disease

M Fontecha-Barriuso, AM Lopez-Diaz… - Antioxidants, 2022 - mdpi.com
Acute kidney injury (AKI) and chronic kidney disease (CKD) are interconnected conditions,
and CKD is projected to become the fifth leading global cause of death by 2040. New …

Prevention of cardiorenal damage: importance of albuminuria

LM Ruilope, A Ortiz, A Lucia, B Miranda… - European Heart …, 2023 - academic.oup.com
Chronic kidney disease (CKD) is projected to become a leading global cause of death by
2040, and its early detection is critical for effective and timely management. The current …

Molecular mechanisms of kidney injury and repair

S Rayego-Mateos, L Marquez-Expósito… - International journal of …, 2022 - mdpi.com
Chronic kidney disease (CKD) will become the fifth global cause of death by 2040, thus
emphasizing the need to better understand the molecular mechanisms of damage and …

EMPA-KIDNEY: expanding the range of kidney protection by SGLT2 inhibitors

B Fernández-Fernandez, P Sarafidis… - Clinical Kidney …, 2023 - academic.oup.com
ABSTRACT In the EMPA-KIDNEY (The Study of Heart and Kidney Protection With
Empagliflozin) trial, empagliflozin reduced cardiorenal outcomes by 28%(hazard ratio 0.72; …

Oxidative stress and cellular senescence are involved in the aging kidney

L Marquez-Exposito, L Tejedor-Santamaria… - Antioxidants, 2022 - mdpi.com
Chronic kidney disease (CKD) can be considered as a clinical model for premature aging.
However, non-invasive biomarkers to detect early kidney damage and the onset of a …

Mineralocorticoid receptor antagonist use in chronic kidney disease with type 2 diabetes: a clinical practice document by the European Renal Best Practice (ERBP) …

P Sarafidis, F Iatridi, C Ferro… - Clinical Kidney …, 2023 - academic.oup.com
Chronic kidney disease (CKD) in individuals with type 2 diabetes (T2D) represents a major
public health issue; it develops in about 30%–40% of patients with diabetes mellitus and is …

Novel aspects of the immune response involved in the peritoneal damage in chronic kidney disease patients under dialysis

F Trionfetti, V Marchant, GT González-Mateo… - International Journal of …, 2023 - mdpi.com
Chronic kidney disease (CKD) incidence is growing worldwide, with a significant percentage
of CKD patients reaching end-stage renal disease (ESRD) and requiring kidney …

Ageing meets kidney disease

A Ortiz, F Mattace-Raso, MJ Soler… - Clinical Kidney …, 2022 - academic.oup.com
Chronic kidney disease (CKD) is defined as abnormalities of kidney structure or function,
present for˃ 3 months, with implications for health. The most used diagnostic criteria are a …

Vitamin D, cellular senescence and chronic kidney diseases: what is missing in the equation?

RP Martinelli, S Rayego-Mateos, M Alique… - Nutrients, 2023 - mdpi.com
As life expectancy increases in many countries, the prevalence of age-related diseases also
rises. Among these conditions, chronic kidney disease is predicted to become the second …