Transfer RNA (tRNA) is an adapter molecule that links a specific codon in mRNA with its
corresponding amino acid during protein synthesis. tRNAs are enzymatically modified post …

The chemical identity of RNA molecules beyond the four standard ribonucleosides has
fascinated scientists since pseudouridine was characterized as the “fifth” ribonucleotide in …

MODOMICS is a database of RNA modifications that provides comprehensive information
concerning the chemical structures of modified ribonucleosides, their biosynthetic pathways …

N 6-methyladenosine is a prevalent internal modification in messenger RNA and non-
coding RNA affecting various cellular pathways. Here we report the discovery of two …

A distinctive feature of prokaryotic gene expression is the absence of 5′-capped RNA. In
eukaryotes, 5′, 5′-triphosphate-linked 7-methylguanosine protects messenger RNA from …

Nature combines existing biochemical building blocks, at times with subtlety of purpose.
RNA modifications are a prime example of this, where standard RNA nucleosides are …

Chemical modifications in RNAs play crucial roles in diversifying their structures and
regulating numerous biochemical processes. Since the 1990s, several hydrophobic prenyl …

Functional tRNA molecules always contain a wide variety of post-transcriptionally modified
nucleosides. These modifications stabilize tRNA structure, allow for proper interaction with …

The field of RNA modifications, so-called epitranscriptomics, has flourished over the past
years owing to improvements of detection methods and the identification of important …

Terpenoids, also known as isoprenoids, are the largest and most diverse class of organic
compounds in nature and are involved in many membrane-associated cellular processes …