Prolonged immunosuppression is increasingly recognized as the major cause of late phase
and long-term mortality in sepsis. Numerous murine models with different paradigms, such …

The wide use of the mouse model of polymicrobial sepsis has provided important evidence
for events occurring in infectious sepsis involving septic mice and septic humans. Nearly …

Sepsis, defined as a dysregulated host immune response to infection, is a common and
dangerous clinical syndrome. The excessive host inflammatory response can induce …

BACKGROUND Sepsis-induced gut microbiome alterations contribute to sepsis-related
morbidity and mortality. Given evidence for improved postsepsis outcomes in females …

Many milestones in medical history rest on animal modeling of human diseases. The SARS-
CoV-2 pandemic has evoked a tremendous investigative effort primarily centered on clinical …

Sepsis is a state of systemic immune dysregulation and organ failure that is frequently
associated with severe brain disability. Epidemiological studies have indicated that younger …

The young population, which is particularly at risk of sepsis, is, paradoxically, rarely studied.
Acute stimulation of O-GlcNAcylation, a post-translational modification involved in metabolic …

Persistent inflammation, immunosuppression, and catabolism syndrome (PIICS) is a
growing challenge in intensive care units (ICUs). PIICS causes a severe illness with high …

1. Kong T, Chung SP, Lee HS, Kim S, Lee J, Hwang SO, Shin SD, Song KJ, Cha KC, You JS,
et al.: The prognostic usefulness of the lactate/albumin ratio for predicting clinical outcomes …