Fatty acids: an insight into the pathogenesis of neurodegenerative diseases and therapeutic potential

DJ Vesga-Jiménez, C Martin, GE Barreto… - International journal of …, 2022 - mdpi.com
One of the most common lipids in the human body is palmitic acid (PA), a saturated fatty acid
with essential functions in brain cells. PA is used by cells as an energy source, besides …

Metabolomics provides novel insights into epilepsy diagnosis and treatment: a review

W Lai, D Du, L Chen - Neurochemical research, 2022 - Springer
Epilepsy is one of the most common diseases of the central nervous system. The diagnosis
of epilepsy mainly depends on electroencephalograms and symptomatology, while …

[HTML][HTML] Lipid profiling of Alzheimer's disease brain highlights enrichment in glycerol (phospho) lipid, and sphingolipid metabolism

S Akyol, Z Ugur, A Yilmaz, I Ustun, SKK Gorti, K Oh… - Cells, 2021 - mdpi.com
Alzheimer's disease (AD) is reported to be closely linked with abnormal lipid metabolism. To
gain a more comprehensive understanding of what causes AD and its subsequent …

Metabolomic changes in adults with status epilepticus: a human case–control study

A Hanin, C Chollet, S Demeret, L Di Meglio… - …, 2024 - Wiley Online Library
Objective Status epilepticus (SE) is a life‐threatening prolonged epileptic seizure that
affects~ 40 per 100 000 people yearly worldwide. The persistence of seizures may lead to …

[HTML][HTML] Systematic review of NMR-based metabolomics practices in human disease research

K Huang, N Thomas, PR Gooley, CW Armstrong - Metabolites, 2022 - mdpi.com
Nuclear magnetic resonance (NMR) spectroscopy is one of the principal analytical
techniques for metabolomics. It has the advantages of minimal sample preparation and high …

[HTML][HTML] Central nervous system metabolism in autism, epilepsy and developmental delays: a cerebrospinal fluid analysis

D Brister, BA Werner, G Gideon, PJ McCarty, A Lane… - Metabolites, 2022 - mdpi.com
Neurodevelopmental disorders are associated with metabolic pathway imbalances;
however, most metabolic measurements are made peripherally, leaving central metabolic …

[HTML][HTML] Epilepsy in pediatric patients—evaluation of brain structures' volume using VolBrain software

MM Woźniak, M Zbroja, M Matuszek… - Journal of clinical …, 2022 - mdpi.com
Epilepsy is one of the most frequent serious brain disorders. Approximately 30,000 of the
150,000 children and adolescents who experience unprovoked seizures are diagnosed with …

Phospholipidomics in clinical trials for brain disorders: advancing our understanding and therapeutic potentials

M Hachem, MK Ahmmed, H Nacir-Delord - Molecular Neurobiology, 2024 - Springer
Phospholipidomics is a specialized branch of lipidomics that focuses on the characterization
and quantification of phospholipids. By using sensitive analytical techniques …

Causal relationship between immune cells and epilepsy mediated by metabolites analyzed through Mendelian randomization

J Chen, H Yu, H Liu, H Yu, S Liang, Q Wu, X Zhang… - Scientific Reports, 2024 - nature.com
Our study investigated the causal relationship between immune cells, metabolites, and
epilepsy using two-sample Mendelian Randomization (MR) and mediation MR analysis of …

From hearth to hard drive: well-being benefits of online Irish traditional singing sessions during COVID-19

C Thompson, KS O'Brien - Health Promotion International, 2022 - academic.oup.com
This article explores the impact of online Irish traditional singing sessions on health and well-
being during the COVID-19 pandemic. Singing sessions are unique facets of Ireland's music …