As a result of the 2019 coronavirus disease pandemic (COVID-19), there has been an
urgent worldwide demand for treatments. Due to factors such as history of prescription for …

Alternative methods to animal use in toxicology are evolving with new advanced tools and
multilevel approaches, to answer from one side to 3Rs requirements, and on the other side …

Simple Summary Hepatocellular carcinoma (HCC) is a highly incident and deadly malignant
neoplasia, and only a few anti-HCC drugs are currently available. Thus, the development of …

Recent global outbreak of the pandemic caused by coronavirus (COVID-19) emphasizes the
urgent need for novel antiviral therapeutics. It can be supplemented by utilization of efficient …

The in vitro micronucleus (MN) assay is a component of most test batteries used in
assessing potential genotoxicity. Our previous study adapted metabolically competent …

The liver is essential in the elimination of environmental and food contaminants. Given the
interspecies differences between rodents and humans, the development of relevant in vitro …

N-nitrosamine impurities have been increasingly detected in human drugs. This is a safety
concern as many nitrosamines are mutagenic in bacteria and carcinogenic in rodent …

The liver is one of the most important multi-functional organs in the human body. Amongst
various crucial functions, it is the main detoxification center and predominantly implicated in …

The micronucleus (MN) assay is a core test used to evaluate genotoxic potential of
xenobiotics. The traditional in vitro MN assay is usually conducted in cells lacking metabolic …

The organotypic human air‐liquid‐interface (ALI) airway tissue model has been used as an
in vitro cell culture system for evaluating the toxicity of inhaled substances. ALI airway …