The regulation and functions of DNA and RNA G-quadruplexes
DNA and RNA can adopt various secondary structures. Four-stranded G-quadruplex (G4)
structures form through self-recognition of guanines into stacked tetrads, and considerable …
structures form through self-recognition of guanines into stacked tetrads, and considerable …
The structure and function of DNA G-quadruplexes
Guanine-rich DNA sequences can fold into four-stranded, noncanonical secondary
structures called G-quadruplexes (G4s). G4s were initially considered a structural curiosity …
structures called G-quadruplexes (G4s). G4s were initially considered a structural curiosity …
DNA G-quadruplexes in the human genome: detection, functions and therapeutic potential
Single-stranded guanine-rich DNA sequences can fold into four-stranded DNA structures
called G-quadruplexes (G4s) that arise from the self-stacking of two or more guanine …
called G-quadruplexes (G4s) that arise from the self-stacking of two or more guanine …
G-quadruplex structures mark human regulatory chromatin
R Hänsel-Hertsch, D Beraldi, SV Lensing, G Marsico… - Nature …, 2016 - nature.com
Abstract G-quadruplex (G4) structural motifs have been linked to transcription 1, 2,
replication 3 and genome instability 4, 5 and are implicated in cancer and other diseases 6 …
replication 3 and genome instability 4, 5 and are implicated in cancer and other diseases 6 …
G-quadruplexes and their regulatory roles in biology
D Rhodes, HJ Lipps - Nucleic acids research, 2015 - academic.oup.com
Abstract 'If G-quadruplexes form so readily in vitro, Nature will have found a way of using
them in vivo'(Statement by Aaron Klug over 30 years ago). During the last decade, four …
them in vivo'(Statement by Aaron Klug over 30 years ago). During the last decade, four …
G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy
Abstract G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that
form within guanine-rich strands of regulatory genomic regions. G4s have been extensively …
form within guanine-rich strands of regulatory genomic regions. G4s have been extensively …
High-throughput sequencing of DNA G-quadruplex structures in the human genome
VS Chambers, G Marsico, JM Boutell… - Nature …, 2015 - nature.com
Abstract G-quadruplexes (G4s) are nucleic acid secondary structures that form within
guanine-rich DNA or RNA sequences. G4 formation can affect chromatin architecture and …
guanine-rich DNA or RNA sequences. G4 formation can affect chromatin architecture and …
Promoter G-quadruplexes and transcription factors cooperate to shape the cell type-specific transcriptome
Cell identity is maintained by activation of cell-specific gene programs, regulated by
epigenetic marks, transcription factors and chromatin organization. DNA G-quadruplex (G4) …
epigenetic marks, transcription factors and chromatin organization. DNA G-quadruplex (G4) …
Quadruplex nucleic acids as novel therapeutic targets
S Neidle - Journal of medicinal chemistry, 2016 - ACS Publications
Quadruplex-forming sequences are widely prevalent in human and other genomes,
including bacterial ones. These sequences are over-represented in eukaryotic telomeres …
including bacterial ones. These sequences are over-represented in eukaryotic telomeres …
Quadruplex nucleic acids as targets for anticancer therapeutics
S Neidle - Nature Reviews Chemistry, 2017 - nature.com
Quadruplex nucleic acids—helical four-stranded structures known to form from guanine-rich
nucleic acid sequences through Hoogsteen-type hydrogen bonding—were once just …
nucleic acid sequences through Hoogsteen-type hydrogen bonding—were once just …