The evolutionary and functional significance of germline immunoglobulin gene variation
The recombination between immunoglobulin (IG) gene segments determines an individual's
naïve antibody repertoire and, consequently,(auto) antigen recognition. Emerging evidence …
naïve antibody repertoire and, consequently,(auto) antigen recognition. Emerging evidence …
Influence of glycosylation on the immunogenicity and antigenicity of viral immunogens
A key aspect of successful viral vaccine design is the elicitation of neutralizing antibodies
targeting viral attachment and fusion glycoproteins that embellish viral particles. This …
targeting viral attachment and fusion glycoproteins that embellish viral particles. This …
Vaccination induces broadly neutralizing antibody precursors to HIV gp41
A key barrier to the development of vaccines that induce broadly neutralizing antibodies
(bnAbs) against human immunodeficiency virus (HIV) and other viruses of high antigenic …
(bnAbs) against human immunodeficiency virus (HIV) and other viruses of high antigenic …
mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies
Z ** of Glycosylated Epitopes Enabled by Online Immobilized Glycosidase
TR O'Leary, D Balasubramaniam, K Hughes… - Analytical …, 2023 - ACS Publications
Hydrogen–deuterium exchange coupled with mass spectrometry (HDX–MS) is widely used
for monoclonal antibody (mAb) epitope map**, which aids in the development of …
for monoclonal antibody (mAb) epitope map**, which aids in the development of …
Mutation-guided vaccine design: A process for develo** boosting immunogens for HIV broadly neutralizing antibody induction
A major goal of HIV-1 vaccine development is the induction of broadly neutralizing
antibodies (bnAbs). Although success has been achieved in initiating bnAb B cell lineages …
antibodies (bnAbs). Although success has been achieved in initiating bnAb B cell lineages …
Visualizing lipid nanoparticle trafficking for mRNA vaccine delivery in non-human primates
ABSTRACT mRNA delivered using lipid nanoparticles (LNPs) has become an important
subunit vaccine modality, but mechanisms of action for mRNA vaccines remain incompletely …
subunit vaccine modality, but mechanisms of action for mRNA vaccines remain incompletely …
Vaccinating people living with HIV: a fast track to preventive and therapeutic HIV vaccines
Globally, the number of new HIV infections remains unacceptably high, and urgent new
approaches are needed to advance HIV vaccine science. However, the development of a …
approaches are needed to advance HIV vaccine science. However, the development of a …