The time-averaged lateral organization of the lipids and proteins that make up mammalian
cell membranes continues to be the subject of intense interest and debate. Since the …

Proteins are often credited as the macromolecule responsible for performing critical cellular
functions, however lipids have recently garnered more attention as our understanding of …

Phospholipids are critical for milk digestion and infant development. But the profile of
phospholipid molecular species in human milk and its dynamic changes during the lactation …

Whether lipid rafts are present in the membranes of living cells remains hotly disputed
despite their incontrovertible existence in liposomes at 298 K. In attempts to resolve this …

The peroxidation of membrane lipids by free radicals contributes to aging, numerous
diseases, and ferroptosis, an iron-dependent form of cell death. Peroxidation changes the …

Fatty Acid Desaturase-1 (FADS1) or delta 5 desaturase (D5D) is a rate-limiting enzyme
involved in the biosynthesis of long-chain polyunsaturated fatty acids (LC-PUFAs), ie …

The combination of supramolecular functional systems with biomolecular chemistry has
been a fruitful exercise for decades, leading to a greater understanding of biomolecules and …

Inter-leaflet coupling is critical to control the dynamics of membrane domain registration/anti-
registration, which is important in maintaining proper biological functions. Factors such as …

Laryngeal cancer is a common head and neck malignant cancer type. However, effective
biomarkers for diagnosis are lacking and pathogenesis is unclear. Lipidomics is a powerful …

In live cells, the plasma membrane is composed of lipid domains separated by hundreds of
nanometers in dynamic equilibrium. Lipid phase separation regulates the trafficking and …