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The gut–joint axis in rheumatoid arthritis
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder that primarily
affects the joints. One hypothesis for the pathogenesis of RA is that disease begins at …
affects the joints. One hypothesis for the pathogenesis of RA is that disease begins at …
Clinical role of human leukocyte antigen in health and disease
YM Mosaad - Scandinavian journal of immunology, 2015 - Wiley Online Library
Most of the genes in the major histocompatibility complex (MHC) region express high
polymorphism that is fundamental for their function. The most important function of human …
polymorphism that is fundamental for their function. The most important function of human …
An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis
Background The adaptive immune response in rheumatoid arthritis (RA) is influenced by an
interaction between host genetics and environment, particularly the host microbiome …
interaction between host genetics and environment, particularly the host microbiome …
Understanding animal welfare
D Fraser - Acta Veterinaria Scandinavica, 2008 - Springer
In debates about the welfare of animals, different people have tended to emphasize different
concerns. Some emphasize the basic health and functioning of animals, especially freedom …
concerns. Some emphasize the basic health and functioning of animals, especially freedom …
Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis
C Carmona-Rivera, PM Carlucci, E Moore… - Science …, 2017 - science.org
Rheumatoid arthritis (RA) is characterized by synovial joint inflammation and by
development of pathogenic humoral and cellular autoimmunity to citrullinated proteins …
development of pathogenic humoral and cellular autoimmunity to citrullinated proteins …
Prevotella histicola Protects From Arthritis by Expansion of Allobaculum and Augmenting Butyrate Production in Humanized Mice
Bacterial therapeutics are the emergent alternatives in treating autoimmune diseases such
as Rheumatoid Arthritis [RA]. P. histicola MCI 001 is one such therapeutic bacterium that has …
as Rheumatoid Arthritis [RA]. P. histicola MCI 001 is one such therapeutic bacterium that has …
Suppression of Inflammatory Arthritis by Human Gut‐Derived Prevotella histicola in Humanized Mice
EV Marietta, JA Murray, DH Luckey… - Arthritis & …, 2016 - Wiley Online Library
Objective The gut microbiome regulates host immune homeostasis. Rheumatoid arthritis
(RA) is associated with intestinal dysbiosis. This study was undertaken to test the ability of a …
(RA) is associated with intestinal dysbiosis. This study was undertaken to test the ability of a …
Utility of animal models for identification of potential therapeutics for rheumatoid arthritis
M Hegen, JC Keith Jr, M Collins… - Annals of the rheumatic …, 2008 - Elsevier
Animal models of rheumatoid arthritis (RA) are widely used for testing potential new
therapies for RA. However, the question of which animal model is most predictive of …
therapies for RA. However, the question of which animal model is most predictive of …
Human leukocyte antigen–disease associations in rheumatoid arthritis
Rheumatoid arthritis (RA) is a common inflammatory disease in which both genetic and
environmental factors play a role in disease development. Based on twin studies, the …
environmental factors play a role in disease development. Based on twin studies, the …
Neutrophil-mediated carbamylation promotes articular damage in rheumatoid arthritis
LJ O'Neil, A Barrera-Vargas, D Sandoval-Heglund… - Science …, 2020 - science.org
Formation of autoantibodies to carbamylated proteins (anti-CarP) is considered detrimental
in the prognosis of erosive rheumatoid arthritis (RA). The source of carbamylated antigens …
in the prognosis of erosive rheumatoid arthritis (RA). The source of carbamylated antigens …