The gut–joint axis in rheumatoid arthritis

MM Zaiss, HJ Joyce Wu, D Mauro, G Schett… - Nature Reviews …, 2021 - nature.com
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder that primarily
affects the joints. One hypothesis for the pathogenesis of RA is that disease begins at …

Clinical role of human leukocyte antigen in health and disease

YM Mosaad - Scandinavian journal of immunology, 2015 - Wiley Online Library
Most of the genes in the major histocompatibility complex (MHC) region express high
polymorphism that is fundamental for their function. The most important function of human …

An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis

J Chen, K Wright, JM Davis, P Jeraldo, EV Marietta… - Genome medicine, 2016 - Springer
Background The adaptive immune response in rheumatoid arthritis (RA) is influenced by an
interaction between host genetics and environment, particularly the host microbiome …

Understanding animal welfare

D Fraser - Acta Veterinaria Scandinavica, 2008 - Springer
In debates about the welfare of animals, different people have tended to emphasize different
concerns. Some emphasize the basic health and functioning of animals, especially freedom …

Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis

C Carmona-Rivera, PM Carlucci, E Moore… - Science …, 2017 - science.org
Rheumatoid arthritis (RA) is characterized by synovial joint inflammation and by
development of pathogenic humoral and cellular autoimmunity to citrullinated proteins …

Prevotella histicola Protects From Arthritis by Expansion of Allobaculum and Augmenting Butyrate Production in Humanized Mice

B Balakrishnan, D Luckey, R Bodhke, J Chen… - Frontiers in …, 2021 - frontiersin.org
Bacterial therapeutics are the emergent alternatives in treating autoimmune diseases such
as Rheumatoid Arthritis [RA]. P. histicola MCI 001 is one such therapeutic bacterium that has …

Suppression of Inflammatory Arthritis by Human Gut‐Derived Prevotella histicola in Humanized Mice

EV Marietta, JA Murray, DH Luckey… - Arthritis & …, 2016 - Wiley Online Library
Objective The gut microbiome regulates host immune homeostasis. Rheumatoid arthritis
(RA) is associated with intestinal dysbiosis. This study was undertaken to test the ability of a …

Utility of animal models for identification of potential therapeutics for rheumatoid arthritis

M Hegen, JC Keith Jr, M Collins… - Annals of the rheumatic …, 2008 - Elsevier
Animal models of rheumatoid arthritis (RA) are widely used for testing potential new
therapies for RA. However, the question of which animal model is most predictive of …

Human leukocyte antigen–disease associations in rheumatoid arthritis

V Van Drongelen, J Holoshitz - Rheumatic Disease Clinics, 2017 - rheumatic.theclinics.com
Rheumatoid arthritis (RA) is a common inflammatory disease in which both genetic and
environmental factors play a role in disease development. Based on twin studies, the …

Neutrophil-mediated carbamylation promotes articular damage in rheumatoid arthritis

LJ O'Neil, A Barrera-Vargas, D Sandoval-Heglund… - Science …, 2020 - science.org
Formation of autoantibodies to carbamylated proteins (anti-CarP) is considered detrimental
in the prognosis of erosive rheumatoid arthritis (RA). The source of carbamylated antigens …