Antibiotic development challenges: the various mechanisms of action of antimicrobial peptides and of bacterial resistance

F Guilhelmelli, N Vilela, P Albuquerque… - Frontiers in …, 2013 - frontiersin.org
Antimicrobial peptides (AMPs) are natural antibiotics produced by various organisms such
as mammals, arthropods, plants, and bacteria. In addition to antimicrobial activity, AMPs can …

Properties and mechanisms of action of naturally occurring antifungal peptides

NL Van der Weerden, MR Bleackley… - Cellular and molecular …, 2013 - Springer
Antimicrobial peptides are a vital component of the innate immune system of all eukaryotic
organisms and many of these peptides have potent antifungal activity. They have potential …

[HTML][HTML] Antimicrobial Peptides with Anti-Candida Activity

A Perez-Rodriguez, E Eraso, G Quindós… - International journal of …, 2022 - mdpi.com
Mycoses are accountable for millions of infections yearly worldwide. Invasive candidiasis is
the most usual, presenting a high morbidity and mortality. Candida albicans remains the …

Tumor cell membrane-targeting cationic antimicrobial peptides: novel insights into mechanisms of action and therapeutic prospects

AA Baxter, FT Lay, IKH Poon, M Kvansakul… - Cellular and Molecular …, 2017 - Springer
There is an ongoing need for effective and targeted cancer treatments that can overcome the
detrimental side effects presented by current treatment options. One class of novel …

Plant defensins and defensin-like peptides-biological activities and biotechnological applications

A de Oliveira Carvalho… - Current pharmaceutical …, 2011 - ingentaconnect.com
Plant defensins are cationic peptides that are ubiquitous within the plant kingdom and
belong to a large superfamily of antimicrobial peptides found in several organisms …

[HTML][HTML] Characterization of dual effects induced by antimicrobial peptides: regulated cell death or membrane disruption

EJ Paredes-Gamero, MNC Martins… - … et Biophysica Acta (BBA …, 2012 - Elsevier
BACKGROUND: Some reports describe lysis mechanisms by antimicrobial peptides (AMPs),
while others describe the activation of regulated cell death. In this study, we compare the cell …

[HTML][HTML] Cationic antimicrobial peptide NRC-03 induces oral squamous cell carcinoma cell apoptosis via CypD-mPTP axis-mediated mitochondrial oxidative stress

D Hou, F Hu, Y Mao, L Yan, Y Zhang, Z Zheng, A Wu… - Redox Biology, 2022 - Elsevier
Pleurocidin-family cationic antimicrobial peptide NRC-03 exhibits potent and selective
cytotoxicity towards cancer cells. However, the anticancer effect of NRC-03 in oral …

Cyclization of the antimicrobial peptide gomesin with native chemical ligation: influences on stability and bioactivity

LY Chan, VM Zhang, Y Huang, NC Waters… - …, 2013 - Wiley Online Library
Gomesin is an 18‐residue peptide originally isolated from the hemocytes of the Brazilian
spider Acanthoscurria gomesiana. A broad spectrum of bioactivities have been attributed to …

[HTML][HTML] Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities

T Wu, M Wang, W Wu, Q Luo, L Jiang, H Tao… - Journal of Venomous …, 2019 - SciELO Brasil
Spider venoms are known to contain proteins and polypeptides that perform various
functions including antimicrobial, neurotoxic, analgesic, cytotoxic, necrotic, and …

Insights into antimicrobial peptides from spiders and scorpions

X Wang, G Wang - Protein and peptide letters, 2016 - ingentaconnect.com
The venoms of spiders and scorpions contain a variety of chemical compounds.
Antimicrobial peptides (AMPs) from these organisms were first discovered in the 1990s. As …