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Antibiotic development challenges: the various mechanisms of action of antimicrobial peptides and of bacterial resistance
Antimicrobial peptides (AMPs) are natural antibiotics produced by various organisms such
as mammals, arthropods, plants, and bacteria. In addition to antimicrobial activity, AMPs can …
as mammals, arthropods, plants, and bacteria. In addition to antimicrobial activity, AMPs can …
Properties and mechanisms of action of naturally occurring antifungal peptides
Antimicrobial peptides are a vital component of the innate immune system of all eukaryotic
organisms and many of these peptides have potent antifungal activity. They have potential …
organisms and many of these peptides have potent antifungal activity. They have potential …
[HTML][HTML] Antimicrobial Peptides with Anti-Candida Activity
Mycoses are accountable for millions of infections yearly worldwide. Invasive candidiasis is
the most usual, presenting a high morbidity and mortality. Candida albicans remains the …
the most usual, presenting a high morbidity and mortality. Candida albicans remains the …
Tumor cell membrane-targeting cationic antimicrobial peptides: novel insights into mechanisms of action and therapeutic prospects
There is an ongoing need for effective and targeted cancer treatments that can overcome the
detrimental side effects presented by current treatment options. One class of novel …
detrimental side effects presented by current treatment options. One class of novel …
Plant defensins and defensin-like peptides-biological activities and biotechnological applications
A de Oliveira Carvalho… - Current pharmaceutical …, 2011 - ingentaconnect.com
Plant defensins are cationic peptides that are ubiquitous within the plant kingdom and
belong to a large superfamily of antimicrobial peptides found in several organisms …
belong to a large superfamily of antimicrobial peptides found in several organisms …
[HTML][HTML] Characterization of dual effects induced by antimicrobial peptides: regulated cell death or membrane disruption
EJ Paredes-Gamero, MNC Martins… - … et Biophysica Acta (BBA …, 2012 - Elsevier
BACKGROUND: Some reports describe lysis mechanisms by antimicrobial peptides (AMPs),
while others describe the activation of regulated cell death. In this study, we compare the cell …
while others describe the activation of regulated cell death. In this study, we compare the cell …
[HTML][HTML] Cationic antimicrobial peptide NRC-03 induces oral squamous cell carcinoma cell apoptosis via CypD-mPTP axis-mediated mitochondrial oxidative stress
D Hou, F Hu, Y Mao, L Yan, Y Zhang, Z Zheng, A Wu… - Redox Biology, 2022 - Elsevier
Pleurocidin-family cationic antimicrobial peptide NRC-03 exhibits potent and selective
cytotoxicity towards cancer cells. However, the anticancer effect of NRC-03 in oral …
cytotoxicity towards cancer cells. However, the anticancer effect of NRC-03 in oral …
Cyclization of the antimicrobial peptide gomesin with native chemical ligation: influences on stability and bioactivity
Gomesin is an 18‐residue peptide originally isolated from the hemocytes of the Brazilian
spider Acanthoscurria gomesiana. A broad spectrum of bioactivities have been attributed to …
spider Acanthoscurria gomesiana. A broad spectrum of bioactivities have been attributed to …
[HTML][HTML] Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities
T Wu, M Wang, W Wu, Q Luo, L Jiang, H Tao… - Journal of Venomous …, 2019 - SciELO Brasil
Spider venoms are known to contain proteins and polypeptides that perform various
functions including antimicrobial, neurotoxic, analgesic, cytotoxic, necrotic, and …
functions including antimicrobial, neurotoxic, analgesic, cytotoxic, necrotic, and …
Insights into antimicrobial peptides from spiders and scorpions
X Wang, G Wang - Protein and peptide letters, 2016 - ingentaconnect.com
The venoms of spiders and scorpions contain a variety of chemical compounds.
Antimicrobial peptides (AMPs) from these organisms were first discovered in the 1990s. As …
Antimicrobial peptides (AMPs) from these organisms were first discovered in the 1990s. As …