Five priorities of African genomics research: the next frontier
To embrace the prospects of accurately diagnosing thousands of monogenic conditions,
predicting disease risks for complex traits or diseases, tailoring treatment to individuals' …
predicting disease risks for complex traits or diseases, tailoring treatment to individuals' …
[PDF][PDF] Barriers to Implementing Clinical Pharmacogenetics Testing in Sub-Saharan Africa. A Critical Review.
Clinical research in high-income countries is increasingly demonstrating the
costeffectiveness of clinical pharmacogenetic (PGx) testing in reducing the incidence of …
costeffectiveness of clinical pharmacogenetic (PGx) testing in reducing the incidence of …
[HTML][HTML] African Pharmacogenomics Consortium: consolidating pharmacogenomics knowledge, capacity development and translation in Africa: consolidating …
Abstract The African Pharmacogenomics Consortium (APC) was formally launched on the
6th September 2018. This white paper outlines its vision, and objectives towards addressing …
6th September 2018. This white paper outlines its vision, and objectives towards addressing …
[HTML][HTML] When the same treatment has different response: The role of pharmacogenomics in statin therapy
E Zheng, P Madura, J Grandos, M Broncel… - Biomedicine & …, 2024 - Elsevier
Statins, also known as HMG-CoA reductase inhibitors, are one of the most potently
prescribed and thoroughly researched medications, predominantly utilized for managing …
prescribed and thoroughly researched medications, predominantly utilized for managing …
[HTML][HTML] Genetic variability and population diversity of the human SLCO (OATP) transporter family
Organic anion transporting polypeptides (OATP) encoded by the SLCO gene family
constitute clinically important transporters involved in the disposition of endogenous …
constitute clinically important transporters involved in the disposition of endogenous …
Warfarin pharmacogenomics for precision medicine in real-life clinical practice in southern Africa: Harnessing 73 variants in 29 pharmacogenes
Pharmacogenomics is universally relevant for worldwide modern therapeutics and yet
needs further development in resource-limited countries. While there is an abundance of …
needs further development in resource-limited countries. While there is an abundance of …
[HTML][HTML] Fluorescence-based methods for studying activity and drug-drug interactions of hepatic solute carrier and ATP binding cassette proteins involved in ADME …
C Özvegy-Laczka, O Ungvári, É Bakos - Biochemical Pharmacology, 2023 - Elsevier
In humans, approximately 70% of drugs are eliminated through the liver. This process is
governed by the concerted action of membrane transporters and metabolic enzymes …
governed by the concerted action of membrane transporters and metabolic enzymes …
Major genetic drivers of statin treatment response in African populations and pharmacogenetics of dyslipidemia through a One Health lens
A One Health lens is increasingly significant to address the intertwined challenges in
planetary health concerned with the health of humans, nonhuman animals, plants, and …
planetary health concerned with the health of humans, nonhuman animals, plants, and …
Towards evidence-based implementation of pharmacogenomics in southern Africa: comorbidities and polypharmacy profiles across diseases
ND Soko, S Muyambo, MTL Dandara… - Journal of Personalized …, 2023 - mdpi.com
Pharmacogenomics may improve patient care by guiding drug selection and dosing;
however, this requires prior knowledge of the pharmacogenomics of drugs commonly used …
however, this requires prior knowledge of the pharmacogenomics of drugs commonly used …
[HTML][HTML] Late response to rosuvastatin and statin-related myalgia due to SLCO1B1, SLCO1B3, ABCB11, and CYP3A5 variants in a patient with Familial …
Statins are the most widely used cholesterol-lowering drugs for cardiovascular diseases
prevention. However, some patients are refractory to treatment, whereas others experience …
prevention. However, some patients are refractory to treatment, whereas others experience …