Over the past five years, a rapidly develo** experimental approach has enabled high-
resolution and high-content information retrieval from intact multicellular animal (metazoan) …

Examination of whole organs with subcellular resolution in health, disease, and during
development is necessary to decipher their biological complexity. However, until recently …

Our understanding of the cellular composition and architecture of cancer has primarily
advanced using 2D models and thin slice samples. This has granted spatial information on …

Breast cancer is a pathological condition characterized by high morphological and
molecular heterogeneity. Not only the breast cancer cells, but also their tumor micro …

Brain atlases enable the map** of labeled cells and projections from different brains onto
a standard coordinate system. We address two issues in the construction and use of atlases …

Polarization sensitive optical coherence tomography (PSOCT) has been shown to image
and delineate white matter fibers in a label-free manner by revealing optical birefringence …

We implemented a wide field-of-view visible-light optical coherence microscope (OCM) for
investigating ex-vivo brain tissue of patients diagnosed with Alzheimer's disease (AD) and of …

Label-free optical microscopy utilizes the information encoded in light scattered off
unlabeled particles to generate the images. This review article starts off with a discussion on …

We present a deep learning framework for volumetric speckle reduction in optical coherence
tomography (OCT) based on a conditional generative adversarial network (cGAN) that …

Modern clearing techniques enable high resolution visualization and 3D reconstruction of
cell populations and their structural details throughout large biological samples, including …