Oxidant mechanisms in renal injury and disease

BB Ratliff, W Abdulmahdi, R Pawar… - Antioxidants & redox …, 2016 - liebertpub.com
Significance: A common link between all forms of acute and chronic kidney injuries,
regardless of species, is enhanced generation of reactive oxygen species (ROS) and …

Monosodium glutamate-induced oxidative kidney damage and possible mechanisms: a mini-review

A Sharma - Journal of biomedical science, 2015 - Springer
Animal studies suggest that chronic monosodium glutamate (MSG) intake induces kidney
damage by oxidative stress. However, the underlying mechanisms are still unclear, despite …

Alpha-lipoic acid attenuates oxidative damage in organs after sepsis

F Petronilho, D Florentino, LG Danielski, LC Vieira… - Inflammation, 2016 - Springer
Sepsis progression is linked with the imbalance between reactive oxygen species and
antioxidant enzymes. Thus, the aim of this study was to evaluate the effect of alpha-lipoic …

Bisdemethoxycurcumin Protects Small Intestine from Lipopolysaccharide‐Induced Mitochondrial Dysfunction via Activating Mitochondrial Antioxidant Systems and …

J Zhang, Y Yang, H Han, L Zhang… - Oxidative Medicine and …, 2021 - Wiley Online Library
Bisdemethoxycurcumin is one of the three curcuminoids of turmeric and exhibits good
antioxidant activity in animal models. This study is aimed at investigating the effect of …

Polyphenol (−)-Epigallocatechin Gallate (EGCG) mitigated kidney injury by regulating metabolic homeostasis and mitochondrial dynamics involvement with Drp1 …

YL Chu, JC Pi, YF Yao, XY Chen, XP Peng… - Food and Chemical …, 2024 - Elsevier
The study aimed to examine effects of (−)-epigallocatechin-3-gallate (EGCG) on energy
metabolism and mitochondrial dynamics in mouse model of renal injury caused by …

Mitochondrial bioenergetics links inflammation and cardiac contractility in endotoxemia

TA Vico, T Marchini, S Ginart, MA Lorenzetti… - Basic Research in …, 2019 - Springer
There is current awareness about the central role of mitochondrial dysfunction in the
development of cardiac dysfunction in systemic inflammatory syndromes, especially in …

α‐Lipoic Acid Targeting PDK1/NRF2 Axis Contributes to the Apoptosis Effect of Lung Cancer Cells

L Yue, Y Ren, Q Yue, Z Ding, K Wang… - Oxidative Medicine …, 2021 - Wiley Online Library
As an antioxidant, α‐lipoic acid (LA) has attracted much attention to cancer research.
However, the exact mechanism of LA in cancer progression control and prevention remains …

Mitochondrial signaling in the vascular endothelium: beyond reactive oxygen species

AO Kadlec, AM Beyer, K Ait-Aissa… - Basic research in …, 2016 - Springer
Traditionally, the mitochondria have been viewed as the cell's powerhouse, producing
energy in the form of ATP. As a byproduct of ATP formation, the mitochondrial electron …

Skeletal muscle pyruvate dehydrogenase phosphorylation and lactate accumulation during sprint exercise in normoxia and severe acute hypoxia: effects of …

D Morales-Alamo, B Guerra, A Santana… - Frontiers in …, 2018 - frontiersin.org
Compared to normoxia, during sprint exercise in severe acute hypoxia the glycolytic rate is
increased leading to greater lactate accumulation, acidification, and oxidative stress. To …

Insights on Localized and Systemic Delivery of Redox‐Based Therapeutics

NE Buglak, EV Batrakova, R Mota… - … medicine and cellular …, 2018 - Wiley Online Library
Reactive oxygen and nitrogen species are indispensable in cellular physiology and
signaling. Overproduction of these reactive species or failure to maintain their levels within …