Foreign body reaction to implanted biomaterials and its impact in nerve neuroprosthetics
The implantation of any foreign material into the body leads to the development of an
inflammatory and fibrotic process—the foreign body reaction (FBR). Upon implantation into a …
inflammatory and fibrotic process—the foreign body reaction (FBR). Upon implantation into a …
Platinum group metals: A review of resources, production and usage with a focus on catalysts
The major applications of PGMs are as catalysts in automotive industry, petroleum refining,
environmental (gas remediation), industrial chemical production (eg, ammonia production …
environmental (gas remediation), industrial chemical production (eg, ammonia production …
Brain tissue responses to neural implants impact signal sensitivity and intervention strategies
Implantable biosensors are valuable scientific tools for basic neuroscience research and
clinical applications. Neurotechnologies provide direct readouts of neurological signal and …
clinical applications. Neurotechnologies provide direct readouts of neurological signal and …
Progress towards biocompatible intracortical microelectrodes for neural interfacing applications
To ensure long-term consistent neural recordings, next-generation intracortical
microelectrodes are being developed with an increased emphasis on reducing the neuro …
microelectrodes are being developed with an increased emphasis on reducing the neuro …
Mechanically-compliant intracortical implants reduce the neuroinflammatory response
Objective. The mechanisms underlying intracortical microelectrode encapsulation and
failure are not well understood. A leading hypothesis implicates the role of the mechanical …
failure are not well understood. A leading hypothesis implicates the role of the mechanical …
The impact of chronic blood–brain barrier breach on intracortical electrode function
Brain-computer interfaces (BCIs) have allowed control of prosthetic limbs in paralyzed
patients. Unfortunately, the electrodes of the BCI that interface with the brain only function for …
patients. Unfortunately, the electrodes of the BCI that interface with the brain only function for …
Flexible, penetrating brain probes enabled by advances in polymer microfabrication
A Weltman, J Yoo, E Meng - Micromachines, 2016 - mdpi.com
The acquisition of high-fidelity, long-term neural recordings in vivo is critically important to
advance neuroscience and brain–machine interfaces. For decades, rigid materials such as …
advance neuroscience and brain–machine interfaces. For decades, rigid materials such as …
Zwitterionic polymer/polydopamine coating reduce acute inflammatory tissue responses to neural implants
The inflammatory brain tissue response to implanted neural electrode devices has hindered
the longevity of these implants. Zwitterionic polymers have a potent anti-fouling effect that …
the longevity of these implants. Zwitterionic polymers have a potent anti-fouling effect that …
Non-transdermal microneedles for advanced drug delivery
Microneedles (MNs) have been used to deliver drugs for over two decades. These platforms
have been proven to increase transdermal drug delivery efficiency dramatically by …
have been proven to increase transdermal drug delivery efficiency dramatically by …
Relationship between intracortical electrode design and chronic recording function
Intracortical electrodes record neural signals directly from local populations of neurons in the
brain, and conduct them to external electronics that control prosthetics. However, the …
brain, and conduct them to external electronics that control prosthetics. However, the …