Foreign body reaction to implanted biomaterials and its impact in nerve neuroprosthetics

A Carnicer-Lombarte, ST Chen… - … in Bioengineering and …, 2021 - frontiersin.org
The implantation of any foreign material into the body leads to the development of an
inflammatory and fibrotic process—the foreign body reaction (FBR). Upon implantation into a …

Platinum group metals: A review of resources, production and usage with a focus on catalysts

AE Hughes, N Haque, SA Northey, S Giddey - Resources, 2021 - mdpi.com
The major applications of PGMs are as catalysts in automotive industry, petroleum refining,
environmental (gas remediation), industrial chemical production (eg, ammonia production …

Brain tissue responses to neural implants impact signal sensitivity and intervention strategies

TDY Kozai, AS Jaquins-Gerstl… - ACS chemical …, 2015 - ACS Publications
Implantable biosensors are valuable scientific tools for basic neuroscience research and
clinical applications. Neurotechnologies provide direct readouts of neurological signal and …

Progress towards biocompatible intracortical microelectrodes for neural interfacing applications

M Jorfi, JL Skousen, C Weder… - Journal of neural …, 2014 - iopscience.iop.org
To ensure long-term consistent neural recordings, next-generation intracortical
microelectrodes are being developed with an increased emphasis on reducing the neuro …

Mechanically-compliant intracortical implants reduce the neuroinflammatory response

JK Nguyen, DJ Park, JL Skousen… - Journal of neural …, 2014 - iopscience.iop.org
Objective. The mechanisms underlying intracortical microelectrode encapsulation and
failure are not well understood. A leading hypothesis implicates the role of the mechanical …

The impact of chronic blood–brain barrier breach on intracortical electrode function

T Saxena, L Karumbaiah, EA Gaupp, R Patkar, K Patil… - Biomaterials, 2013 - Elsevier
Brain-computer interfaces (BCIs) have allowed control of prosthetic limbs in paralyzed
patients. Unfortunately, the electrodes of the BCI that interface with the brain only function for …

Flexible, penetrating brain probes enabled by advances in polymer microfabrication

A Weltman, J Yoo, E Meng - Micromachines, 2016 - mdpi.com
The acquisition of high-fidelity, long-term neural recordings in vivo is critically important to
advance neuroscience and brain–machine interfaces. For decades, rigid materials such as …

Zwitterionic polymer/polydopamine coating reduce acute inflammatory tissue responses to neural implants

A Golabchi, B Wu, B Cao, CJ Bettinger, XT Cui - Biomaterials, 2019 - Elsevier
The inflammatory brain tissue response to implanted neural electrode devices has hindered
the longevity of these implants. Zwitterionic polymers have a potent anti-fouling effect that …

Non-transdermal microneedles for advanced drug delivery

KJ Lee, MJ Goudie, P Tebon, W Sun, Z Luo… - Advanced drug delivery …, 2020 - Elsevier
Microneedles (MNs) have been used to deliver drugs for over two decades. These platforms
have been proven to increase transdermal drug delivery efficiency dramatically by …

Relationship between intracortical electrode design and chronic recording function

L Karumbaiah, T Saxena, D Carlson, K Patil, R Patkar… - Biomaterials, 2013 - Elsevier
Intracortical electrodes record neural signals directly from local populations of neurons in the
brain, and conduct them to external electronics that control prosthetics. However, the …