Multiple neurodegenerative diseases are characterized by single-protein dysfunction and
aggregation. Treatment strategies for these diseases have often targeted downstream …

Antisense oligonucleotides are synthetic single stranded strings of nucleic acids that bind to
RNA and thereby alter or reduce expression of the target RNA. They can not only reduce …

Aerobes require oxygen for metabolism and normal free radical formation. As a result,
maintaining the redox homeostasis is essential for brain cell survival due to their high …

Gain-of-function mutations in the Cu, Zn-superoxide dismutase (SOD1) gene are implicated
in progressive motor neuron death and paralysis in one form of inherited amyotrophic lateral …

Therapeutic success in the superoxide dismutase (SOD1) mouse model of amyotrophic
lateral sclerosis (ALS) has not translated into effective therapy for human ALS, calling into …

During neuronal development, neurotrophins are essential factors that promote survival,
differentiation and myelination of neurons. The trophic signals are relayed to the cells via …

Peptide nucleic acids (PNAs) are synthetic nucleic acid analogs with a neutral N-(2-
aminoethyl) glycine backbone. PNAs possess unique physicochemical characteristics such …

A strong glial reaction typically surrounds the affected upper and lower motor neurons and
degenerating descending tracts of ALS patients. Reactive astrocytes in ALS contain protein …

The strong repair and pro-survival functions of neurotrophins at their primary receptors, TrkA,
TrkB and TrkC, have made them attractive candidates for treatment of nervous system injury …

Amyotrophic lateral sclerosis (ALS) is a severely debilitating disease characterized by
progressive degeneration of motor neurons. Charcot first described ALS in 18691; however …