Inflammatory bowel disease (IBD) manifests as intestinal barrier destruction, mucosal
immunity dysregulation, and disrupted gut microbiome homeostasis. Conventional anti …

Small-angle and ultra-small-angle X-ray and neutron scattering techniques provide
structural information on the nanometre-to-micron length scale. This review describes recent …

Amorphous solid dispersion (ASD) technology is an attractive formulation approach for
poorly soluble drugs because of the supersaturated state acquired during its dissolution …

Intestinal anastomotic leaking, which involves the discharge of chemically aggressive, non‐
sterile fluids into the abdomen, remains one of the most dreaded postoperative …

Bacterial invasion into eukaryotic cells and the establishment of intracellular infection has
proven to be an effective means of resisting antibiotic action, as anti‐infective agents …

Transient permeability enhancers (PEs), such as caprylate, caprate, and salcaprozate
sodium (SNAC), improve the bioavailability of poorly permeable macromolecular drugs …

Hypotheses Bile salts (BS) are biosurfactants released into the small intestine, which play
key and contrasting roles in lipid digestion: they adsorb at interfaces and promote the …

Purpose Asperosaponin VI (ASP VI) as an active ingredient of Dipsacus asperoides, which
has a wide range of biological and pharmacological activity. However, its development and …

Adsorption of gut relevant biomolecules onto particles after oral administration of solid oral
dosage forms is expected to form a “gastrointestinal corona”, which could influence solution …

Bile salts are biosurfactants that can induce structure transformations in supramolecular
nanoassemblies with conventional surfactants owing to their unique, planar amphiphilic …