Small-molecule drug discovery has traditionally focused on occupancy of a binding site that
directly affects protein function, and this approach typically precludes targeting proteins that …

The nuclear factor‐κB (NF‐κB) transcription factor family has been considered the central
mediator of the inflammatory process and a key participant in innate and adaptive immune …

Eukaryotic cell biology depends on cullin–RING E3 ligase (CRL)-catalysed protein
ubiquitylation, which is tightly controlled by the modification of cullin with the ubiquitin-like …

Osteoarthritis is one of the leading causes of pain and disability in the aged population due
to articular cartilage damage. This warrants investigation of signaling mechanisms that could …

Inflammation is a fundamental protective response that sometimes goes awry and becomes
a major cofactor in the pathogenesis of many chronic human diseases, including cancer …

Hepatic cirrhosis and hepatocellular carcinoma (HCC) are the most common causes of
death in patients with chronic liver disease. Chronic liver injury of virtually any etiology …

Nuclear factor-κB (NF-κB) consists of a family of transcription factors that play critical roles in
inflammation, immunity, cell proliferation, differentiation, and survival. Inducible NF-κB …

An elaborate network of highly inducible proteins protects aerobic cells against the
cumulative damaging effects of reactive oxygen intermediates and toxic electrophiles, which …

The intracellular levels of many proteins are regulated by ubiquitin-dependent proteolysis.
One of the best-characterized enzymes that catalyzes the attachment of ubiquitin to proteins …

Post-translational modifications of proteins and the domains that recognize these
modifications have central roles in creating a highly dynamic relay system that reads and …