[HTML][HTML] Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria

Y Liu, Z Tong, J Shi, R Li, M Upton, Z Wang - Theranostics, 2021 - ncbi.nlm.nih.gov
Antimicrobial resistance has been a global health challenge that threatens our ability to
control and treat life-threatening bacterial infections. Despite ongoing efforts to identify new …

β-lactam Resistance in Pseudomonas aeruginosa: Current Status, Future Prospects

KA Glen, IL Lamont - Pathogens, 2021 - mdpi.com
Pseudomonas aeruginosa is a major opportunistic pathogen, causing a wide range of acute
and chronic infections. β-lactam antibiotics including penicillins, carbapenems …

Efflux pump inhibitors of clinically relevant multidrug resistant bacteria

A Lamut, L Peterlin Mašič, D Kikelj… - Medicinal Research …, 2019 - Wiley Online Library
Bacterial infections are an increasingly serious issue worldwide. The inability of existing
therapies to treat multidrug‐resistant pathogens has been recognized as an important …

Similarities and differences between silver ions and silver in nanoforms as antibacterial agents

A Kędziora, M Speruda, E Krzyżewska, J Rybka… - International journal of …, 2018 - mdpi.com
Silver is considered as antibacterial agent with well-known mode of action and bacterial
resistance against it is well described. The development of nanotechnology provided …

Multidrug efflux pumps at the crossroad between antibiotic resistance and bacterial virulence

M Alcalde-Rico, S Hernando-Amado, P Blanco… - Frontiers in …, 2016 - frontiersin.org
Multidrug efflux pumps can be involved in bacterial resistance to antibiotics at different
levels. Some efflux pumps are constitutively expressed at low levels and contribute to …

[HTML][HTML] Esca** mechanisms of ESKAPE pathogens from antibiotics and their targeting by natural compounds

R Jadimurthy, SB Mayegowda, SC Nayak… - Biotechnology …, 2022 - Elsevier
The microorganisms that have developed resistance to available therapeutic agents are
threatening the globe and multidrug resistance among the bacterial pathogens is becoming …

Distribution and spread of the mobilised RND efflux pump gene cluster tmexCD-toprJ in clinical Gram-negative bacteria: a molecular epidemiological study

N Dong, Y Zeng, Y Wang, C Liu, J Lu, C Cai… - The Lancet …, 2022 - thelancet.com
Summary Background TMexCD1-TOprJ1, which is associated with phenotypic resistance to
multiple classes of antibiotics, is a transmissible resistance-nodulation-division (RND) family …

RND efflux pumps in Gram-negative bacteria; regulation, structure and role in antibiotic resistance

AL Colclough, I Alav, EE Whittle, HL Pugh… - Future …, 2020 - Taylor & Francis
Rresistance-nodulation-division (RND) efflux pumps in Gram-negative bacteria remove
multiple, structurally distinct classes of antimicrobials from inside bacterial cells therefore …

Triclosan: Antimicrobial mechanisms, antibiotics interactions, clinical applications, and human health

P Shrestha, Y Zhang, WJ Chen… - Journal of Environmental …, 2020 - Taylor & Francis
The large-scale applications of Triclosan in industrial and household products have created
many health and environmental concerns. Despite the fears of its drug-resistance and other …

The balance between antibiotic resistance and fitness/virulence in Pseudomonas aeruginosa: an update on basic knowledge and fundamental research

E Jordana-Lluch, IM Barceló… - Frontiers in …, 2023 - frontiersin.org
The interplay between antibiotic resistance and bacterial fitness/virulence has attracted the
interest of researchers for decades because of its therapeutic implications, since it is …