Autophagy in major human diseases
Autophagy is a core molecular pathway for the preservation of cellular and organismal
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
homeostasis. Pharmacological and genetic interventions impairing autophagy responses …
Coeliac disease pathogenesis: the uncertainties of a well-known immune mediated disorder
Coeliac disease is a common small bowel enteropathy arising in genetically predisposed
individuals and caused by ingestion of gluten in the diet. Great advances have been made …
individuals and caused by ingestion of gluten in the diet. Great advances have been made …
Cystic fibrosis, CFTR, and colorectal cancer
P Scott, K Anderson, M Singhania… - International journal of …, 2020 - mdpi.com
Cystic fibrosis (CF), caused by biallelic inactivating mutations in the cystic fibrosis
transmembrane conductance regulator (CFTR) gene, has recently been categorized as a …
transmembrane conductance regulator (CFTR) gene, has recently been categorized as a …
[HTML][HTML] Role of ion channels in gastrointestinal cancer
KJ Anderson, RT Cormier, PM Scott - World Journal of …, 2019 - ncbi.nlm.nih.gov
In their seminal papers Hanahan and Weinberg described oncogenic processes a normal
cell undergoes to be transformed into a cancer cell. The functions of ion channels in the …
cell undergoes to be transformed into a cancer cell. The functions of ion channels in the …
Therapeutic modulation of autophagy: which disease comes first?
MC Maiuri, G Kroemer - Cell Death & Differentiation, 2019 - nature.com
The relentless efforts of thousands of researchers have allowed deciphering the molecular
machinery that regulates and executes autophagy, thus identifying multiple molecular …
machinery that regulates and executes autophagy, thus identifying multiple molecular …
The gliadin p31–43 peptide: Inducer of multiple proinflammatory effects
Coeliac disease (CD) is the prototype of an inflammatory chronic disease induced by food.
In this context, gliadin p31–43 peptide comes into the spotlight as an important player of the …
In this context, gliadin p31–43 peptide comes into the spotlight as an important player of the …
Gut microbiota‐CRAMP axis shapes intestinal barrier function and immune responses in dietary gluten‐induced enteropathy
In the gut, cathelicidin‐related antimicrobial peptide (CRAMP) has been largely described
for its anti‐infective activities. With an increasing recognition of its immune regulatory effects …
for its anti‐infective activities. With an increasing recognition of its immune regulatory effects …
Human organoids and organ-on-chips in coeliac disease research
HL Simpson, E Smits, R Moerkens, C Wijmenga… - Trends in Molecular …, 2024 - cell.com
Coeliac disease (CeD) is an immune-mediated disorder characterised by gluten-triggered
inflammation and damage in the small intestine, with lifelong gluten-free diet (GFD) as the …
inflammation and damage in the small intestine, with lifelong gluten-free diet (GFD) as the …
Structural conformation and self‐assembly process of p31‐43 gliadin peptide in aqueous solution. Implications for celiac disease
Celiac disease (CeD) is a highly prevalent chronic immune‐mediated enteropathy
developed in genetically predisposed individuals after ingestion of a group of wheat proteins …
developed in genetically predisposed individuals after ingestion of a group of wheat proteins …
Gliadin proteolytical resistant peptides: the interplay between structure and self-assembly in gluten-related disorders
In recent years, the evaluation of the structural properties of food has become of crucial
importance in the understanding of food-related disorders. One of the most exciting systems …
importance in the understanding of food-related disorders. One of the most exciting systems …