The cardiovascular toxicity of older generation of tricyclic antidepressants (eg imipramine,
desipramine, amitriptyline, clomipramine) and neuroleptics (eg haloperidol, droperidol …

Since the introduction of tricyclic antidepressants (TCAs) and monoamine oxidase inhibitors
(MAOIs) in mid-1950's, treatment of depression has been dominated by monoamine …

Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) are widely used
in studying basic mechanisms of cardiac arrhythmias that are caused by ion …

Drug-induced delayed cardiac repolarization is a recognized risk factor for proarrhythmia
and is associated with block of I Kr (the potassium current encoded by the human ether-a-go …

Brugada syndrome is an inherited cardiac arrhythmia condition characterized by (i) coved
ST-elevation and J point elevation of at least 2 mm in at least two of the right precordial ECG …

Abstract SEA0400 and KB-R7943 are compounds synthesised to block transsarcolemmal
Na+/Ca 2+ exchange current (I Na/Ca); however, they Have also been shown to inhibit L …

Using whole-cell patch clamp recording of heterologous HERG-mediated currents in
transfected mammalian cells, we observed that the selective serotonin re-uptake inhibitor …

Fluoxetine is a commonly prescribed antidepressant compound. Its action is primarily
attributed to selective inhibition of the reuptake of serotonin (5-hydroxytryptamine) in the …

Psychotropic Drugs and ST Segment Elevation. Transient ST segment elevation in right
precordial leads with use of psychotropic drugs is reported in two cases of overdose and …

HERG (human-ether-a-go-go-related gene) encodes for a cardiac potassium channel that
plays a critical role in defining ventricular repolarization. Noncardiovascular drugs …