Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations
KJ Gardiner - Drug design, development and therapy, 2014 - Taylor & Francis
Down syndrome (DS), also known as trisomy 21, is the most common genetic cause of
intellectual disability (ID). Although ID can be mild, the average intelligence quotient is in the …
intellectual disability (ID). Although ID can be mild, the average intelligence quotient is in the …
Application of quality by design in optimization of nanoformulations: Principle, perspectives and practices
Nanoparticulate drug delivery systems (NDDS) based nanoformulations have emerged as
promising drug delivery systems. Various NDDS-based formulations have been reported …
promising drug delivery systems. Various NDDS-based formulations have been reported …
A general pharmacodynamic interaction model identifies perpetrators and victims in drug interactions
Assessment of pharmacodynamic (PD) drug interactions is a cornerstone of the
development of combination drug therapies. To guide this venture, we derive a general …
development of combination drug therapies. To guide this venture, we derive a general …
Toxicity evaluation of microplastics to aquatic organisms through molecular simulations and fractional factorial designs
Molecular docking, molecular dynamics modelling, and fractional factorial design
methodologies were used in the current work to examine the harmful effects of ten …
methodologies were used in the current work to examine the harmful effects of ten …
Output-driven feedback system control platform optimizes combinatorial therapy of tuberculosis using a macrophage cell culture model
Tuberculosis (TB) remains a major global public health problem, and improved treatments
are needed to shorten duration of therapy, decrease disease burden, improve compliance …
are needed to shorten duration of therapy, decrease disease burden, improve compliance …
Statistical modeling enabled design of high-performance conductive composite fiber materials for energy harvesting and self-powered sensing
Fiber-based triboelectric nanogenerators (TENGs) composed of conductive electrode and
triboelectric materials are capable of converting mechanical energy into electricity. Core …
triboelectric materials are capable of converting mechanical energy into electricity. Core …
Drug regimens identified and optimized by output-driven platform markedly reduce tuberculosis treatment time
BY Lee, DL Clemens, A Silva, BJ Dillon… - Nature …, 2017 - nature.com
The current drug regimens for treating tuberculosis are lengthy and onerous, and hence
complicated by poor adherence leading to drug resistance and disease relapse. Previously …
complicated by poor adherence leading to drug resistance and disease relapse. Previously …
Combining two-level and three-level orthogonal arrays for factor screening and response surface exploration
Experimental design and analysis is an effective and commonly used tool in scientific
investigations and industrial applications. Orthogonal arrays, such as factorial and fractional …
investigations and industrial applications. Orthogonal arrays, such as factorial and fractional …
Space-filling fractional factorial designs
Fractional factorial designs are widely used in various scientific investigations and industrial
applications. Level permutation of factors could alter their geometrical structures and …
applications. Level permutation of factors could alter their geometrical structures and …
Degradation characteristics of metoprolol during UV/chlorination reaction and a factorial design optimization
Metoprolol (MTP), a hypertension depressor, has been increasingly detected even after
conventional water treatment processes. In this study, the removal of MTP was compared …
conventional water treatment processes. In this study, the removal of MTP was compared …