Degeneracy in epilepsy: multiple routes to hyperexcitable brain circuits and their repair

TM Stöber, D Batulin, J Triesch, R Narayanan… - Communications …, 2023‏ - nature.com
Due to its complex and multifaceted nature, develo** effective treatments for epilepsy is
still a major challenge. To deal with this complexity we introduce the concept of degeneracy …

The enigmatic HCN channels: A cellular neurophysiology perspective

P Mishra, R Narayanan - Proteins: Structure, Function, and …, 2025‏ - Wiley Online Library
What physiological role does a slow hyperpolarization‐activated ion channel with mixed
cation selectivity play in the fast world of neuronal action potentials that are driven by …

Multimodal modeling of neural network activity: computing LFP, ECoG, EEG, and MEG signals with LFPy 2.0

E Hagen, S Næss, TV Ness… - Frontiers in …, 2018‏ - frontiersin.org
Recordings of extracellular electrical, and later also magnetic, brain signals have been the
dominant technique for measuring brain activity for decades. The interpretation of such …

Multimodal determinants of phase-locked dynamics across deep-superficial hippocampal sublayers during theta oscillations

A Navas-Olive, M Valero, T Jurado-Parras… - Nature …, 2020‏ - nature.com
Theta oscillations play a major role in temporarily defining the hippocampal rate code by
translating behavioral sequences into neuronal representations. However, mechanisms …

Theta and gamma rhythmic coding through two spike output modes in the hippocampus during spatial navigation

E Lowet, DJ Sheehan, U Chialva, RDO Pena… - Cell reports, 2023‏ - cell.com
Hippocampal CA1 neurons generate single spikes and stereotyped bursts of spikes.
However, it is unclear how individual neurons dynamically switch between these output …

Uncovering circuit mechanisms of current sinks and sources with biophysical simulations of primary visual cortex

AE Rimehaug, AJ Stasik, E Hagen, YN Billeh… - elife, 2023‏ - elifesciences.org
Local field potential (LFP) recordings reflect the dynamics of the current source density
(CSD) in brain tissue. The synaptic, cellular, and circuit contributions to current sinks and …

[کتاب][B] Electric brain signals: foundations and applications of biophysical modeling

G Halnes, TV Ness, S Næss, E Hagen, KH Pettersen… - 2024‏ - books.google.com
It is common to study the electric activity of neurons by measuring the electric potential in the
extracellular space of the brain. However, interpreting such measurements requires …

Hyperpolarization-activated cyclic nucleotide-gated channels: an emerging role in neurodegenerative diseases

X Chang, J Wang, H Jiang, L Shi, J **e - Frontiers in molecular …, 2019‏ - frontiersin.org
Neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD),
amyotrophic lateral sclerosis (ALS), and spinal muscular atrophy (SMA) are chronic …

Degeneracy in hippocampal physiology and plasticity

RK Rathour, R Narayanan - Hippocampus, 2019‏ - Wiley Online Library
Degeneracy, defined as the ability of structurally disparate elements to perform analogous
function, has largely been assessed from the perspective of maintaining robustness of …

[HTML][HTML] Active dendrites and local field potentials: biophysical mechanisms and computational explorations

M Sinha, R Narayanan - Neuroscience, 2022‏ - Elsevier
Neurons and glial cells are endowed with membranes that express a rich repertoire of ion
channels, transporters, and receptors. The constant flux of ions across the neuronal and glial …