Drug repurposing has become an effective approach to drug discovery, as it offers a new
way to explore drugs. Based on the Science Citation Index Expanded (SCI-E) and Social …

In recent years, drug repositioning has emerged as a promising alternative to the time-
consuming, expensive and risky process of develo** new drugs for diseases. However …

Tumour heterogeneity is one of the main characteristics of cancer and can be categorised
into inter‐or intratumour heterogeneity. This heterogeneity has been revealed as one of the …

We present Beyondcell, a computational methodology for identifying tumour cell
subpopulations with distinct drug responses in single-cell RNA-seq data and proposing …

Background Systemic lupus erythematosus (SLE) is an autoimmune disease that involves
multiple organs. However, the current SLE-related biomarkers still lack sufficient sensitivity …

Lupus nephritis (LN) is the most common and significant complication of systemic lupus
erythematosus (SLE) due to its poor prognosis and mortality rates in SLE patients. There is a …

Colon cancer (CC) is one of the most common gastrointestinal malignant tumors with a high
mortality rate. Glycolysis is an important pathway for tumors to obtain energy. However, its …

Background Gastric cancer patients with peritoneal metastasis (GCPM) experience a rapidly
deteriorating clinical trajectory characterized by therapeutic resistance and dismal survival …

Drug repositioning is the identification of interactions between drugs and target proteins in
pharmaceutical sciences. Traditional large-scale validation through chemical experiments is …

Background Effective drugs for tendinopathy are lacking, resulting in significant morbidity
and re-tearing rate after operation. Applying systems biology to identify new applications for …