Integration of GC–MS and LC–MS for untargeted metabolomics profiling

ÖC Zeki, CC Eylem, T Reçber, S Kır… - Journal of Pharmaceutical …, 2020 - Elsevier
Recently, metabolomics analyses have become increasingly common in the general
scientific community as it is applied in several researches relating to diseases diagnosis …

Modern analytical techniques in metabolomics analysis

A Zhang, H Sun, P Wang, Y Han, X Wang - Analyst, 2012 - pubs.rsc.org
Metabolomics is the comprehensive assessment of endogenous metabolites and attempts to
systematically identify and quantify metabolites from a biological sample. Small-molecule …

Mass spectrometry‐based plant metabolomics: Metabolite responses to abiotic stress

TF Jorge, JA Rodrigues, C Caldana… - Mass spectrometry …, 2016 - Wiley Online Library
Metabolomics is one omics approach that can be used to acquire comprehensive
information on the composition of a metabolite pool to provide a functional screen of the …

New advances in separation science for metabolomics: resolving chemical diversity in a post-genomic era

NL Kuehnbaum, P Britz-McKibbin - Chemical reviews, 2013 - ACS Publications
Metabolomics offers a revolutionary framework for phenoty** individuals at a molecular
level that is needed for new breakthroughs in cell biology and personalized medicine. 1− 3 …

Untargeted LC/MS-based metabolic phenoty** (metabonomics/metabolomics): The state of the art

H Gika, C Virgiliou, G Theodoridis, RS Plumb… - … of Chromatography B, 2019 - Elsevier
Liquid chromatography (LC) hyphenated to mass spectrometry is currently the most widely
used means of determining metabolic phenotypes via both untargeted and targeted …

Toward global metabolomics analysis with hydrophilic interaction liquid chromatography–mass spectrometry: improved metabolite identification by retention time …

DJ Creek, A Jankevics, R Breitling, DG Watson… - Analytical …, 2011 - ACS Publications
Metabolomics is an emerging field of postgenomic biology concerned with comprehensive
analysis of small molecules in biological systems. However, difficulties associated with the …

Toward 'omic scale metabolite profiling: a dual separation–mass spectrometry approach for coverage of lipid and central carbon metabolism

J Ivanisevic, ZJ Zhu, L Plate, R Tautenhahn… - Analytical …, 2013 - ACS Publications
Although the objective of any 'omic science is broad measurement of its constituents, such
coverage has been challenging in metabolomics because the metabolome is comprised of a …

Optimized Analytical Procedures for the Untargeted Metabolomic Profiling of Human Urine and Plasma by Combining Hydrophilic Interaction (HILIC) and Reverse …

K Contrepois, L Jiang, M Snyder - Molecular & Cellular Proteomics, 2015 - ASBMB
Profiling of body fluids is crucial for monitoring and discovering metabolic markers of health
and disease and for providing insights into human physiology. Since human urine and …

Advances in metabolite identification

DS Wishart - Bioanalysis, 2011 - Taylor & Francis
One of the central challenges to metabolomics is metabolite identification. Regardless of
whether one uses so-called 'targeted'or 'untargeted'metabolomics, eventually all paths lead …

An introduction to liquid chromatography–mass spectrometry instrumentation applied in plant metabolomic analyses

JW Allwood, R Goodacre - Phytochemical Analysis: An …, 2010 - Wiley Online Library
Over the past decade the application of non‐targeted high‐throughput metabolomic analysis
within the plant sciences has gained ever increasing interest and has truly established itself …