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Treating head and neck cancer in the age of immunotherapy: a 2023 update
A Bhatia, B Burtness - Drugs, 2023 - Springer
Most patients diagnosed with head and neck squamous cell carcinoma (HNSCC) will
present with locally advanced disease, requiring multimodality therapy. While this approach …
present with locally advanced disease, requiring multimodality therapy. While this approach …
Targeted therapy for head and neck cancer: signaling pathways and clinical studies
Head and neck cancer (HNC) is malignant, genetically complex and difficult to treat and is
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …
the sixth most frequent cancer, with tobacco, alcohol and human papillomavirus being major …
Tislelizumab plus chemotherapy as first-line treatment for recurrent or metastatic nasopharyngeal cancer: A multicenter phase 3 trial (RATIONALE-309)
Y Yang, J Pan, H Wang, Y Zhao, S Qu, N Chen, X Chen… - Cancer cell, 2023 - cell.com
Checkpoint inhibitors are effective in recurrent/metastatic nasopharyngeal cancer (R/M
NPC). RATIONALE-309 (NCT03924986) randomized 263 treatment-naive R/M NPC …
NPC). RATIONALE-309 (NCT03924986) randomized 263 treatment-naive R/M NPC …
Phase I/Ib clinical trial of sabatolimab, an anti–TIM-3 antibody, alone and in combination with spartalizumab, an anti–PD-1 antibody, in advanced solid tumors
Abstract Purpose: Sabatolimab (MBG453) and spartalizumab are mAbs that bind T-cell
immunoglobulin domain and mucin domain-3 (TIM-3) and programmed death-1 (PD-1) …
immunoglobulin domain and mucin domain-3 (TIM-3) and programmed death-1 (PD-1) …
Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) is an aggressive malignancy with extremely skewed
ethnic and geographic distributions. Increasing evidence indicates that targeting the tumor …
ethnic and geographic distributions. Increasing evidence indicates that targeting the tumor …
Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution
The heterogeneous nature of tumour microenvironment (TME) underlying diverse treatment
responses remains unclear in nasopharyngeal carcinoma (NPC). Here, we profile 176,447 …
responses remains unclear in nasopharyngeal carcinoma (NPC). Here, we profile 176,447 …
Comprehensive single-cell sequencing reveals the stromal dynamics and tumor-specific characteristics in the microenvironment of nasopharyngeal carcinoma
The tumor microenvironment (TME) of nasopharyngeal carcinoma (NPC) harbors a
heterogeneous and dynamic stromal population. A comprehensive understanding of this …
heterogeneous and dynamic stromal population. A comprehensive understanding of this …
Nasopharyngeal carcinoma
Nasopharyngeal carcinoma is characterised by distinct geographical distribution and is
particularly prevalent in east and southeast Asia. Epidemiological trends in the past decade …
particularly prevalent in east and southeast Asia. Epidemiological trends in the past decade …
Single-cell and spatial transcriptome analyses reveal tertiary lymphoid structures linked to tumour progression and immunotherapy response in nasopharyngeal …
Tertiary lymphoid structures are immune cell aggregates linked with cancer outcomes, but
their interactions with tumour cell aggregates are unclear. Using nasopharyngeal carcinoma …
their interactions with tumour cell aggregates are unclear. Using nasopharyngeal carcinoma …
Single-cell transcriptomic analysis defines the interplay between tumor cells, viral infection, and the microenvironment in nasopharyngeal carcinoma
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated malignancy
with a complex tumor ecosystem. How the interplay between tumor cells, EBV, and the …
with a complex tumor ecosystem. How the interplay between tumor cells, EBV, and the …